| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2 |
| Entrez GeneID | 2146 |
| WB Predicted band size | Calculated MW: 85 kDa; Observed MW: 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human KMT6/EZH2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于KMT6(EZH2)抗体的关键文献摘要：
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1. **文献名称**: *Role of EZH2 in Germinal Center Formation and Lymphomagenesis*
**作者**: Béguelin, W. 等 (2013)
**摘要**: 研究利用KMT6/EZH2抗体分析B细胞淋巴瘤中H3K27me3修饰水平，发现EZH2突变通过异常表观调控促进肿瘤发生，为靶向治疗提供依据。
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2. **文献名称**: *EZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations*
**作者**: Sneeringer, C.J. 等 (2010)
**摘要**: 通过KMT6抗体检测突变型EZH2的活性，验证其与H3K27三甲基化的关联，并证明小分子抑制剂可特异性阻断该酶功能。
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3. **文献名称**: *Structural Basis for the Recognition of Histone H3K27me3 by the PRC2 Complex*
**作者**: Margueron, R. 等 (2012)
**摘要**: 研究使用KMT6抗体进行免疫共沉淀(Co-IP)，揭示PRC2复合体中EZH2与H3K27me3结合的结构机制，阐明表观遗传沉默的分子基础。
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**说明**：以上文献均涉及KMT6(EZH2)抗体的实验应用，涵盖癌症机制、药物开发和表观遗传调控研究。建议通过PubMed或期刊数据库获取完整文本以验证细节。
The KMT6 antibody targets the KMT6 protein, also known as EZH2 (Enhancer of Zeste Homolog 2), a catalytic subunit of the Polycomb Repressive Complex 2 (PRC2). PRC2 is a key epigenetic regulator that trimethylates histone H3 at lysine 27 (H3K27me3), a modification associated with transcriptional repression. KMT6/EZH2 plays a critical role in maintaining cellular identity by silencing genes involved in differentiation, cell cycle control, and apoptosis. Dysregulation of KMT6/EZH2 is linked to various cancers, where its overexpression correlates with tumor progression, metastasis, and poor prognosis. It is also implicated in stem cell maintenance and developmental processes.
The KMT6 antibody is widely used in research to study PRC2-mediated epigenetic mechanisms, assess EZH2 expression levels in cancer tissues (e.g., breast, prostate, and lymphoma), and investigate its role in chromatin remodeling. Applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP-seq). Additionally, KMT6 antibodies are employed in drug development, particularly for evaluating inhibitors like tazemetostat, an FDA-approved EZH2-targeting therapy for certain cancers. By enabling precise detection of KMT6/EZH2. this antibody serves as a vital tool for advancing our understanding of epigenetic regulation and its therapeutic potential.
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