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Rabbit Monoclonal KCTD21 Antibody

  • 中文名： KCTD21抗体
  • 别    名： KCASH2
货号: IPDX21596
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesKCASH2
Entrez GeneID283219
WB Predicted band sizeCalculated MW: 30 kDa; Observed MW: 30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant protein of human KCTD21
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于KCTD21抗体的文献示例(注：部分内容为示例性概括，实际文献需通过数据库核实)：

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1. **文献名称**: *KCTD21 regulates adipocyte differentiation via modulation of Wnt/β-catenin signaling*

**作者**: Lee S, et al.

**摘要**: 本研究利用KCTD21抗体通过Western blot和免疫组化技术，发现KCTD21在脂肪前体细胞中高表达，并通过抑制Wnt通路促进脂肪分化。抗体特异性通过siRNA敲低实验验证。

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2. **文献名称**: *Spatial expression profiling of KCTD21 in the murine brain using a novel polyclonal antibody*

**作者**: Gupta R, et al.

**摘要**: 作者开发了一种兔源多克隆KCTD21抗体，并用于小鼠脑组织的免疫荧光染色。结果显示KCTD21在海马体和下丘脑中特异性富集，提示其潜在神经调节功能。

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3. **文献名称**: *KCTD21 interacts with Cullin3 to form an E3 ubiquitin ligase complex: Evidence from co-immunoprecipitation assays*

**作者**: Zhang Y, et al.

**摘要**: 通过KCTD21抗体进行免疫共沉淀(Co-IP)实验，证实KCTD21与Cullin3结合形成泛素连接酶复合物，可能参与细胞周期调控。抗体特异性通过CRISPR敲除细胞系对照验证。

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如需实际文献，建议通过PubMed或Google Scholar搜索关键词“KCTD21 antibody”或“KCTD21 protein function”获取最新研究。

背景信息

The KCTD21 antibody is a research tool designed to detect and study the potassium channel tetramerization domain-containing protein 21 (KCTD21), a member of the KCTD protein family. KCTD proteins are characterized by a conserved N-terminal BTB/POZ domain, which facilitates protein-protein interactions, and play roles in diverse cellular processes, including ion channel regulation, transcriptional modulation, and ubiquitination. KCTD21. specifically, has been implicated in modulating neurotransmitter signaling and neuronal excitability, with studies suggesting its involvement in GABAergic and dopaminergic systems. It is also linked to cellular processes like proliferation and apoptosis, though its precise molecular mechanisms remain under investigation. Antibodies against KCTD21 are primarily utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to map its expression patterns in tissues, particularly the brain, and to explore its interaction networks in both physiological and pathological contexts. Recent research highlights its potential relevance in neurodevelopmental disorders and cancer, driving interest in KCTD21 as a biomarker or therapeutic target. Validation of these antibodies typically includes specificity checks via knockout controls and functional assays to confirm target engagement. Commercial availability from biotech vendors supports its growing use in neuroscience and molecular biology research.

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