| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAPK9; JNK2; PRKM9; SAPK1A; Mitogen-activated protein kinase 9; MAP kinase 9; MAPK 9; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2 |
| Entrez GeneID | 5601 |
| WB Predicted band size | Calculated MW: 48 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human JNK2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于JNK2抗体的典型参考文献示例(内容基于公开研究整理，非真实引用)：
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1. **文献名称**：*Selective Inhibition of JNK2 by a Novel Antibody for Targeted Therapy in Inflammatory Diseases*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种高特异性JNK2单克隆抗体，验证了其在Western blot及免疫组化中对JNK2的选择性识别(不交叉反应JNK1/JNK3)，并在小鼠关节炎模型中证明其抑制炎症反应的效果。
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2. **文献名称**：*Role of JNK2 in Neuronal Apoptosis: Insights from Antibody-Based Functional Blockade*
**作者**：Chen L, et al.
**摘要**：通过特异性JNK2抗体阻断实验，揭示JNK2在氧化应激诱导的神经元凋亡中的关键作用，并证实其磷酸化c-Jun的活性依赖于JNK2亚型，为神经退行性疾病治疗提供新靶点。
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3. **文献名称**：*Characterization of a Phospho-Specific JNK2 Antibody for Monitoring Activation States in Tumors*
**作者**：Wang X, et al.
**摘要**：报道了一种针对JNK2 Thr183/Tyr185磷酸化位点的抗体，验证了其在癌症组织芯片中检测JNK2激活状态的应用，并发现JNK2活性与乳腺癌患者预后负相关。
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4. **文献名称**：*Comparative Analysis of JNK Isoform Antibodies in Knockout Validation Models*
**作者**：Johnson R, et al.
**摘要**：系统评估了多种商业JNK2抗体的特异性，利用JNK2基因敲除小鼠组织样本，发现部分抗体存在非特异性结合，强调抗体验证在信号通路研究中的必要性。
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(注：以上文献为示例性质，实际引用需查询PubMed等数据库获取真实论文。)
The c-Jun N-terminal kinase 2 (JNK2) antibody is a crucial tool for studying the JNK signaling pathway, which regulates cellular responses to stress, apoptosis, proliferation, and differentiation. JNK2. encoded by the *MAPK9* gene, is a serine/threonine kinase belonging to the mitogen-activated protein kinase (MAPK) family. It shares structural homology with JNK1 and JNK3. featuring a conserved kinase domain and phosphorylation sites (Thr183/Tyr185). JNK2 is activated by upstream kinases (MKK4/MKK7) in response to cytokines, UV radiation, or oxidative stress, subsequently phosphorylating substrates like c-Jun, ATF2. and p53.
JNK2-specific antibodies enable the detection of JNK2 expression, localization, and activation status in cells and tissues. Phosphorylation-specific antibodies distinguish active (phosphorylated) JNK2 from its inactive form, providing insights into pathway dynamics. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research applications include studying JNK2's role in cancer (e.g., tumor survival, drug resistance), neurodegenerative diseases (e.g., Alzheimer’s), and inflammatory disorders. Compared to JNK1 (ubiquitous) and JNK3 (neuron-specific), JNK2 exhibits broader tissue distribution but functional redundancy with JNK1 complicates its analysis, emphasizing the need for isoform-specific antibodies. Validated JNK2 antibodies are essential for clarifying its distinct contributions to cellular processes and therapeutic targeting.
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