| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SF; MGF; SCF; SLF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7; DFNA69 |
| Entrez GeneID | 4254 |
| clone | 2E1F9 |
| WB Predicted band size | 30.9kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human KITLG (AA: Extra(26-214)) expressed in Mammalian |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ITPK1抗体的示例参考文献(仅供参考，具体文献需通过学术数据库验证)：
1. **"Development and validation of a polyclonal antibody for detecting human ITPK1 in cellular models"**
*Authors: Smith J, Lee R, Brown A*
摘要：本研究开发了一种针对ITPK1的多克隆抗体，通过Western blot和免疫组化验证其特异性，并应用于研究ITPK1在HEK293细胞中的亚细胞定位。
2. **"ITPK1 modulates T-cell activation through inositol phosphate signaling: evidence from antibody-mediated inhibition"**
*Authors: Garcia M, Tanaka K, Wei L*
摘要：利用抗ITPK1抗体阻断其活性，发现ITPK1通过调节肌醇磷酸代谢影响T细胞活化和炎症因子分泌，提示其在免疫调控中的关键作用。
3. **"Antibody-based profiling of ITPK1 expression in colorectal cancer tissues"**
*Authors: Chen X, Wang Y, Zhou H*
摘要：通过免疫组织化学分析ITPK1抗体标记的结直肠癌组织，发现ITPK1高表达与患者预后不良相关，为癌症治疗提供了潜在靶点。
4. **"Characterization of ITPK1 knockout mice using specific antibody probes"**
*Authors: Müller S, Fischer P, Grewal T*
摘要：在ITPK1基因敲除小鼠模型中，利用特异性抗体验证蛋白缺失，并揭示ITPK1缺失导致胚胎发育异常和代谢紊乱的机制。
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**备注**：以上文献为示例性质，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“ITPK1 antibody”、“ITPK1 detection”)获取。建议结合具体研究领域筛选近年发表的论文。
The ITPK1 (Inositol-trisphosphate 3-kinase) antibody is a research tool used to study the ITPK1 enzyme, which plays a critical role in inositol phosphate metabolism. ITPK1 catalyzes the phosphorylation of inositol 1.4.5-trisphosphate (IP3) to inositol 1.3.4.5-tetrakisphosphate (IP4), a key step in modulating cellular signaling pathways linked to calcium regulation, gene expression, and cellular proliferation. Dysregulation of ITPK1 has been implicated in immune disorders, neurological conditions, and cancer, making it a target for mechanistic and therapeutic studies.
Antibodies against ITPK1 enable researchers to detect and quantify the protein’s expression levels, localization, and interactions in various biological samples. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). High-quality ITPK1 antibodies are validated for specificity and sensitivity, often through knockout controls or siRNA knockdowns, ensuring reliable experimental outcomes.
Recent studies highlight ITPK1's role in T-cell signaling, autophagy, and tumor suppression, emphasizing the antibody's utility in dissecting disease mechanisms. Commercial antibodies are available as monoclonal or polyclonal variants, with epitope-specific options for tailored applications. By facilitating precise detection of ITPK1. these antibodies contribute to advancing our understanding of inositol phosphate signaling networks and their implications in health and disease.
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