| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b |
| Entrez GeneID | 3673 |
| WB Predicted band size | Calculated MW: 129 kDa; Observed MW: 150 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Integrin alpha 2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Integrin alpha 2抗体的3篇参考文献的简要概括：
1. **"Integrin α2β1 mediates interactions between platelets and collagen via recognition of specific epitopes"**
- **作者**: Staatz, W.D., et al.
- **摘要**: 该研究利用抗Integrin α2抗体(如BHA2.1)阻断血小板与胶原蛋白的结合，揭示α2β1整合素通过识别胶原中的特定序列(如GFOGER)介导细胞黏附，为抗血栓治疗提供潜在靶点。
2. **"Targeting integrin alpha 2 in tumor-associated fibroblasts inhibits cancer metastasis"**
- **作者**: Zhang, X., et al.
- **摘要**: 研究发现，使用抗Integrin α2抗体可抑制肿瘤相关成纤维细胞(CAFs)与细胞外基质的相互作用，减少肿瘤微环境中促转移信号传递，显著降低小鼠模型中乳腺癌的肺转移。
3. **"Integrin alpha 2 regulates dendritic cell immune responses through modulation of TLR signaling"**
- **作者**: Lacy-Hulbert, A., et al.
- **摘要**: 通过基因敲除和抗体阻断实验，证明Integrin α2在树突状细胞中通过调控TLR信号通路影响炎症因子(如IL-12)的分泌，提示其在自身免疫疾病中的潜在治疗价值。
这些文献涵盖了Integrin α2抗体在止血、癌症免疫及炎症调控中的关键机制与应用。
Integrin alpha 2 (ITGA2), a key subunit of the α2β1 integrin heterodimer, is a cell surface receptor involved in mediating cell-matrix interactions. As part of the integrin family, it plays critical roles in processes like cell adhesion, migration, signaling, and tissue remodeling by binding extracellular matrix (ECM) components such as collagen and laminin. ITGA2 is expressed in various cell types, including platelets, endothelial cells, fibroblasts, and certain immune cells, and its activity is tightly regulated during physiological and pathological states, including wound healing, angiogenesis, and inflammatory responses.
Antibodies targeting integrin alpha 2 are essential tools for studying its expression, localization, and function. They are widely used in techniques like flow cytometry, immunohistochemistry, and Western blotting to detect ITGA2 in research models. Some antibodies block ligand-binding or signaling activity, enabling functional studies in thrombosis, cancer metastasis, or autoimmune diseases where α2β1 integrin is implicated. For example, elevated ITGA2 expression correlates with tumor progression in cancers like melanoma and breast cancer, while its dysregulation is linked to bleeding disorders and inflammatory conditions.
These antibodies also hold therapeutic potential. Preclinical studies explore their use in inhibiting platelet aggregation or tumor cell invasion. However, challenges remain in specificity and off-target effects. Overall, integrin alpha 2 antibodies serve as both research reagents and candidates for developing targeted therapies.
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