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Rabbit Monoclonal IKBbeta Antibody

  • 中文名: IKB beta抗体
  • 别    名: NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9
货号: IPDX21554
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CNR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3条关于IκBβ抗体的**示例参考文献**(基于假设性研究,供格式参考):

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1. **文献名称**:*"IκBβ-specific antibody reveals distinct roles in NF-κB signaling and inflammatory responses"*

**作者**:Chen, L., et al.

**摘要**:本研究开发了一种高特异性IκBβ单克隆抗体,验证了其在Western blot和免疫荧光中的应用。通过抑制实验发现,IκBβ在非经典NF-κB通路中调控巨噬细胞的炎症因子释放,提示其作为炎症疾病的潜在治疗靶点。

2. **文献名称**:*"Dynamic phosphorylation of IκBβ in T cell activation: Insights from antibody-based assays"*

**作者**:Rodriguez, S., et al.

**摘要**:利用磷酸化特异性IκBβ抗体,作者揭示了T细胞激活过程中IκBβ的磷酸化动力学。研究发现,IκBβ的降解速度较IκBα更慢,可能通过稳定p50/p65二聚体延长NF-κB的促存活信号。

3. **文献名称**:*"Targeting IκBβ degradation with neutralizing antibodies for cancer therapy"*

**作者**:Wang, Y., et al.

**摘要**:通过筛选阻断IκBβ降解的抗体,研究者发现其能抑制NF-κB过度活化,从而增强肿瘤细胞对化疗的敏感性。抗体在体外和小鼠模型中均显示出抗肿瘤活性,为靶向IκBβ的癌症治疗提供了新策略。

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**说明**:以上文献为示例性质,实际引用需查询真实数据库(如PubMed)。若需具体文献,建议通过关键词“IκBβ antibody”或“NFKBIB antibody”在学术平台检索。

背景信息

IκBβ (Inhibitor of Nuclear Factor Kappa B Beta) is a member of the IκB protein family that regulates the activity of NF-κB transcription factors, which play pivotal roles in immune responses, inflammation, and cell survival. Unlike IκBα, which is rapidly degraded upon stimulation, IκBβ exhibits delayed degradation and unique regulatory dynamics, enabling prolonged or distinct NF-κB activation patterns. IκBβ binds to NF-κB dimers (e.g., p50/p65) in the cytoplasm, sequestering them from the nucleus. Upon cellular stimuli (e.g., cytokines, pathogens), IκB kinases (IKKs) phosphorylate IκBβ, leading to its ubiquitination and proteasomal degradation. This releases NF-κB, allowing its nuclear translocation and target gene activation.

Antibodies targeting IκBβ are essential tools for studying NF-κB signaling dynamics. They enable detection of IκBβ expression, phosphorylation status, and degradation via techniques like Western blotting, immunofluorescence, or immunoprecipitation. Research using IκBβ antibodies has revealed its tissue-specific roles, such as in B-cell development and chronic inflammatory diseases. Dysregulation of IκBβ-NF-κB interactions is implicated in cancers, autoimmune disorders, and neurodegenerative conditions, making these antibodies valuable for mechanistic studies and therapeutic target validation. Their specificity and sensitivity are critical for distinguishing IκBβ from other IκB isoforms, aiding precise pathway dissection.

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