| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 1; HSD17; EDHB17; EDH17B2; SDR28C1 |
| Entrez GeneID | 3292 |
| WB Predicted band size | Calculated MW: 35 kDa; Observed MW: 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human HSD17B1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于HSD17B1抗体的3篇参考文献示例(注：文献信息为模拟，实际引用需核实)：
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1. **文献名称**：*Immunohistochemical analysis of HSD17B1 expression in human breast cancer*
**作者**：Smith A, et al.
**摘要**：本研究通过HSD17B1抗体进行免疫组化分析，发现HSD17B1在乳腺癌组织中高表达，并与雌激素受体阳性亚型显著相关，提示其在雌激素依赖性肿瘤进展中的潜在作用。
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2. **文献名称**：*Role of HSD17B1 in ovarian steroidogenesis: Insights from antibody-based localization*
**作者**：Chen L, et al.
**摘要**：利用HSD17B1特异性抗体进行亚细胞定位研究，证实该酶在卵巢颗粒细胞线粒体中富集，支持其参与雌二醇合成的功能，为多囊卵巢综合征的机制研究提供依据。
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3. **文献名称**：*Development and validation of a novel HSD17B1 monoclonal antibody for biochemical assays*
**作者**：Wang Y, et al.
**摘要**：报道一种新型HSD17B1单克隆抗体的开发与验证，该抗体在Western blot和免疫沉淀中表现出高特异性，适用于定量检测多种组织样本中的HSD17B1蛋白水平。
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(注：以上文献信息为示例，实际研究中请通过PubMed或Google Scholar以“HSD17B1 antibody”为关键词检索最新文献。)
The HSD17B1 antibody is a crucial tool for studying the 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) enzyme, which plays a pivotal role in steroid hormone metabolism. HSD17B1 catalyzes the conversion of estrone (E1) to the biologically active estradiol (E2), a key estrogen regulating reproductive functions, bone health, and cellular proliferation. Dysregulation of HSD17B1 has been implicated in estrogen-dependent pathologies, including breast cancer, endometriosis, and ovarian disorders.
Antibodies targeting HSD17B1 enable researchers to detect, quantify, and localize the enzyme in tissues and cell lines. These antibodies are widely used in techniques such as immunohistochemistry (IHC), Western blotting, and immunofluorescence to investigate HSD17B1 expression patterns in normal and diseased states. For instance, elevated HSD17B1 levels in breast tumors correlate with poor prognosis, underscoring its potential as a therapeutic target.
Most HSD17B1 antibodies are raised against specific epitopes of the human enzyme, often validated for cross-reactivity in model organisms. They aid in elucidating the enzyme's role in steroidogenic pathways and its interaction with cofactors like NADPH. Recent studies also explore HSD17B1 inhibitors for cancer therapy, further highlighting the antibody's utility in preclinical research. Understanding HSD17B1's function through antibody-based assays contributes to advancing diagnostics and targeted treatments for hormone-related diseases.
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