| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3 |
| Entrez GeneID | 3107 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human HLA-C |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于HLA-C抗体的3篇参考文献示例(部分信息为模拟，建议结合实际文献调整)：
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1. **文献名称**：*HLA-C Antibodies in Kidney Transplantation: Impact on Graft Survival and Rejection*
**作者**：Susal, C., & Schaefer, J.
**摘要**：探讨HLA-C抗体在肾移植中的临床意义，发现其与抗体介导的排斥反应(AMR)相关，强调术前抗体筛查对改善移植预后的重要性。
2. **文献名称**：*Maternal HLA-C Antibodies and Pregnancy Complications: A Systematic Review*
**作者**：Moffett, A., et al.
**摘要**：分析母体HLA-C抗体在妊娠中的作用，提出异常抗体水平可能与复发性流产、先兆子痫等并发症相关，提示免疫调节机制的关键性。
3. **文献名称**：*HLA-C Antibody Detection: Advances in Solid-Phase Assays*
**作者**：Tait, B. D., et al.
**摘要**：比较新型固相检测技术(如Luminex)与传统方法对HLA-C抗体的敏感性和特异性，强调高灵敏度检测在临床移植和输血中的应用价值。
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**备注**：以上文献信息为示例性质，实际引用时建议通过PubMed或Google Scholar检索最新文献(如关键词：HLA-C antibodies, transplantation, pregnancy, detection)，并核对作者、标题及摘要准确性。
Human leukocyte antigen (HLA) antibodies, including those targeting HLA-C, are immune proteins produced when individuals are exposed to foreign HLA molecules, typically through pregnancy, blood transfusions, or organ transplants. HLA-C is a class I HLA molecule encoded by the highly polymorphic HLA-C gene on chromosome 6. Unlike HLA-A and HLA-B, HLA-C exhibits lower cell surface expression but plays a critical role in immune regulation, particularly in natural killer (NK) cell interactions via killer immunoglobulin-like receptors (KIRs).
HLA-C antibodies arise when the immune system recognizes mismatched HLA-C antigens as non-self. In transplantation, these antibodies can mediate graft rejection by activating complement-dependent cytotoxicity or antibody-dependent cellular mechanisms. They are also implicated in pregnancy-related complications, such as recurrent miscarriage or preeclampsia, due to maternal-fetal HLA-C incompatibility. Detection of HLA-C antibodies is performed using solid-phase assays like single-antigen bead (SAB) tests, which identify specific antibody-antigen interactions.
Clinically, HLA-C antibodies are considered less immunogenic than HLA-A/B antibodies but still contribute to transplant sensitization and alloimmune responses. Their significance varies depending on antibody strength, specificity, and patient context. Research continues to clarify their role in immune tolerance, graft survival, and reproductive health, emphasizing the need for precise monitoring in HLA-matched therapies.
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