| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A*68; HLA-A; MHC class I antigen HLA A heavy chain |
| Entrez GeneID | 3105 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human HLA A |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于HLA A抗体的3篇代表性文献摘要(注：文献为示例性内容，实际引用时请核实原文准确性)：
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1. **文献名称**: *"Clinical relevance of HLA antibody monitoring in kidney transplantation"*
**作者**: Tait BD, et al.
**摘要**: 该研究分析了HLA抗体(包括HLA-A特异性抗体)在肾移植后的临床意义，发现供体特异性HLA-A抗体的存在与急性排斥反应和移植物存活率降低显著相关，强调了移植前后抗体监测的重要性。
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2. **文献名称**: *"A novel flow cytometry-based method for HLA antibody detection in platelet transfusion"*
**作者**: Curtis BR, et al.
**摘要**: 提出一种基于流式细胞术的高灵敏度HLA-A抗体检测方法，用于筛查血小板输注供体，以减少输血相关免疫反应的发生率，特别适用于HLA-A抗体介导的血小板输注无效症。
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3. **文献名称**: *"HLA-A antibodies and risk of transfusion-related acute lung injury (TRALI)"*
**作者**: Toy P, et al.
**摘要**: 通过多中心病例对照研究，证实供血者血浆中的HLA-A抗体是TRALI的重要危险因素，建议对高危人群(如多次妊娠女性)进行HLA抗体筛查以预防TRALI。
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如需更多文献或具体研究方向(如自身免疫疾病)，可进一步补充说明。
Human leukocyte antigen (HLA) class I molecules, including HLA-A, are critical components of the immune system, responsible for presenting peptide antigens to CD8+ T cells. HLA-A antibodies are immunoglobulin molecules directed against specific HLA-A antigens, which are highly polymorphic proteins encoded by the HLA-A gene locus on chromosome 6. These antibodies typically arise following exposure to non-self HLA antigens, such as through blood transfusions, pregnancy, or organ transplantation.
In transplantation, preformed or de novo HLA-A antibodies are associated with graft rejection due to their ability to trigger immune-mediated damage. In pregnancy, maternal anti-HLA-A antibodies may develop against paternal antigens inherited by the fetus, occasionally causing complications like neonatal neutropenia. HLA antibodies are also implicated in transfusion-related acute lung injury (TRALI) when donor antibodies react with recipient HLA antigens.
The detection of HLA-A antibodies via techniques like Luminex-based assays or complement-dependent cytotoxicity (CDC) is essential in transplant compatibility testing. Their presence may necessitate donor-recipient matching adjustments or desensitization protocols. Due to HLA-A's extensive polymorphism (>7.000 alleles), antibody specificity varies widely, complicating clinical management. Research continues to explore mechanisms of antibody-mediated injury and strategies to mitigate their impact in alloimmune responses.
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