| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase GSK3A |
| Entrez GeneID | 2931 |
| WB Predicted band size | Calculated MW: 51 kDa; Observed MW: 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human GSK3 alpha |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与GSK3α抗体相关的参考文献，按文献名称、作者和摘要内容概括：
1. **文献名称**：*"A novel monoclonal antibody specifically recognizes the active form of GSK-3α"*
**作者**：Li et al. (2018)
**摘要**：研究团队开发了一种特异性识别磷酸化GSK3α(Ser21位点)的单克隆抗体，验证了其在Western blot和免疫荧光中的应用，证明其可用于检测细胞分化过程中GSK3α活性变化。
2. **文献名称**：*"GSK3α ablation in mice reveals its critical role in cardiomyocyte homeostasis"*
**作者**：Zhou et al. (2020)
**摘要**：通过使用GSK3α特异性抗体进行组织染色，研究发现GSK3α基因敲除小鼠心肌细胞中β-catenin信号异常激活，揭示了GSK3α在心脏稳态调控中的关键作用。
3. **文献名称**：*"Differential roles of GSK3α and GSK3β in Alzheimer’s disease pathology"*
**作者**：Hernandez et al. (2019)
**摘要**：利用亚型特异性抗体区分GSK3α和GSK3β，发现GSK3α在阿尔茨海默病模型小鼠中特异性促进tau蛋白过度磷酸化，提示其作为治疗靶点的潜力。
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**注**：以上文献信息为示例性质，实际文献需通过PubMed或Web of Science检索确认。若需具体文献，建议补充实验背景(如物种、应用场景)以进一步筛选。
The glycogen synthase kinase 3 alpha (GSK3α) is a serine/threonine kinase belonging to the GSK3 family, which includes two isoforms, GSK3α and GSK3β, encoded by distinct genes. GSK3α plays critical roles in cellular signaling pathways, including Wnt/β-catenin, insulin, and growth factor signaling, regulating processes such as glycogen metabolism, cell proliferation, differentiation, and apoptosis. Unlike GSK3β, which has been extensively studied, GSK3α shares structural similarities but exhibits distinct regulatory mechanisms and substrate preferences, partly due to differences in its N-terminal region.
Antibodies targeting GSK3α are essential tools for detecting and analyzing its expression, post-translational modifications (e.g., phosphorylation at Ser21), and subcellular localization in various biological contexts. These antibodies enable researchers to investigate GSK3α's involvement in diseases such as Alzheimer's disease, diabetes, and cancer, where dysregulated GSK3α activity is implicated. Specificity is a key consideration, as cross-reactivity with GSK3β must be minimized. Validated antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore tissue-specific expression patterns, interaction partners, and therapeutic targeting. Recent studies also highlight GSK3α's unique roles in metabolic disorders, driving interest in isoform-specific inhibitors. High-quality GSK3α antibodies thus support both basic research and drug discovery efforts aimed at modulating its activity for therapeutic benefit.
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