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Rabbit Monoclonal GrowthHormoneReceptor Antibody

  • 中文名： Growth Hormone Receptor抗体
  • 别    名： GHR; Growth hormone receptor; GH receptor; Somatotropin receptor
货号: IPDX21471
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Rat
IF 1/20 Rat
IHC 咨询技术 Rat
ICC 技术咨询 Rat
FCM 咨询技术 Rat
Elisa 咨询技术 Rat

产品详情

AliasesGHR; Growth hormone receptor; GH receptor; Somatotropin receptor
Entrez GeneID2690
WB Predicted band sizeCalculated MW: 72 kDa; Observed MW: 120 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityRat
ImmunogenA synthetic peptide of human Growth hormone receptor
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于生长激素受体(GHR)抗体的代表性文献摘要(虚构示例，仅作格式参考)：

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1. **文献名称**：*Structural basis for growth hormone receptor activation and ligand specificity*

**作者**：Smith A, et al. (1999)

**摘要**：通过X射线晶体学解析了GHR胞外结构域与生长激素的复合物结构，揭示了抗体结合表位对受体二聚化和信号传导的关键作用。

2. **文献名称**：*Monoclonal antibodies targeting the extracellular domain of GHR block STAT5 signaling*

**作者**：Johnson R, et al. (2005)

**摘要**：开发了两种单克隆抗体(mAb3和mAb7)，证明其通过阻断GHR二聚化抑制JAK2-STAT5信号通路，为肿瘤治疗提供潜在策略。

3. **文献名称**：*Anti-GHR antibody as a therapeutic agent for obesity-related metabolic disorders*

**作者**：Lee S, et al. (2020)

**摘要**：在小鼠模型中验证了一种人源化抗GHR抗体(hGHRab-2)可通过调节脂肪组织代谢改善胰岛素抵抗，提示其在代谢疾病中的应用潜力。

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注：以上为模拟内容，实际文献需通过PubMed或Google Scholar检索关键词“Growth Hormone Receptor antibody”获取。

背景信息

Growth hormone receptor (GHR) antibodies are biological tools or therapeutic agents targeting the GHR, a transmembrane protein critical for mediating the effects of growth hormone (GH) in regulating growth, metabolism, and cellular repair. GHR belongs to the cytokine receptor superfamily and activates intracellular signaling pathways, primarily JAK2/STAT, upon GH binding. Antibodies against GHR are broadly categorized into agonists, antagonists, or neutralizing types, each with distinct applications. In research, GHR antibodies are used to study receptor expression, localization, and signaling mechanisms, aiding in understanding conditions like growth disorders, metabolic syndromes, and aging. Therapeutically, monoclonal antibodies (e.g., pegvisomant) act as antagonists to block GH-GHR interaction, offering treatment for acromegaly by reducing insulin-like growth factor 1 (IGF-1) overproduction. Neutralizing antibodies may also emerge in rare autoimmune contexts, causing GH resistance syndromes resembling Laron syndrome. Recent advances explore bispecific antibodies or conjugates targeting GHR in cancers, leveraging its overexpression in certain tumors. Challenges include optimizing specificity to minimize off-target effects and addressing receptor dimerization complexities. Overall, GHR antibodies bridge basic research and clinical innovation, with ongoing studies expanding their diagnostic and therapeutic potential in endocrinology and oncology.

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