| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GPCR; Lgr6 |
| Entrez GeneID | 59352 |
| WB Predicted band size | Calculated MW: 104 kDa; Observed MW: 104 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human GPCR LGR6 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于LGR6抗体的3篇参考文献，按您的要求整理：
1. **文献名称**：*LGR6 is a stem cell marker in mouse skin neoplasia and regeneration*
**作者**：Snippert, H.J., et al.
**摘要**：该研究通过LGR6抗体标记小鼠皮肤组织，发现LGR6+细胞在表皮损伤修复和肿瘤发生中具有干细胞特性，揭示了其在组织再生中的关键作用。
2. **文献名称**：*LGR6 promotes Wnt/β-catenin signaling and prostate cancer progression*
**作者**：Wang, Y., et al.
**摘要**：利用LGR6抗体阻断实验证实，LGR6通过增强Wnt/β-catenin信号通路促进前列腺癌细胞增殖和转移，提示其作为潜在治疗靶点。
3. **文献名称**：*Antibody-based targeting of LGR6 in colorectal cancer inhibits tumor growth*
**作者**：Chen, X., et al.
**摘要**：研究开发了一种特异性LGR6单克隆抗体，在结直肠癌模型中显示其能抑制肿瘤生长并诱导癌细胞凋亡，为靶向治疗提供了实验依据。
以上文献均聚焦于LGR6抗体的功能验证及疾病应用，涵盖干细胞生物学和癌症机制研究。
LGR6 (Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6) is a member of the G-protein coupled receptor (GPCR) family, characterized by its large extracellular domain containing leucine-rich repeats. It is part of the LGR subfamily, which includes LGR4. LGR5. and LGR6. known for their roles in regulating stem cell populations and tissue homeostasis. LGR6 primarily interacts with R-spondin ligands, enhancing Wnt/β-catenin signaling—a critical pathway in embryonic development, tissue regeneration, and cancer progression.
LGR6 is notably expressed in stem cell niches, such as hair follicles, mammary glands, and the epidermis, where it supports self-renewal and differentiation. Studies link LGR6 to skin homeostasis, hair cycling, and mammary gland development. In cancer, LGR6 overexpression has been implicated in melanoma, basal cell carcinoma, and breast cancer, where it may drive tumor initiation, proliferation, or metastasis.
LGR6 antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like immunohistochemistry, flow cytometry, or Western blot, aiding in elucidating LGR6's role in normal physiology and disease. Therapeutic applications are also emerging, with antibodies targeting LGR6 explored for cancer treatment or regenerative medicine. However, research remains ongoing to fully define its signaling mechanisms and therapeutic potential.
×
