| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Golgin subfamily A member 1 (Golgin-97) |
| Entrez GeneID | 2800 |
| WB Predicted band size | Calculated MW: 88 kDa; Observed MW: 88 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Golgin 97 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于GOLGA1抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *Autoantibodies to Golgin-1 (GOLGA1) in Rheumatoid Arthritis and Systemic Autoimmune Diseases*
**作者**: Smith A, et al.
**摘要**: 本研究利用GOLGA1抗体检测类风湿性关节炎(RA)患者血清中的自身抗体，发现GOLGA1自身抗体可能与RA的疾病活动度相关，并提示高尔基体蛋白在系统性自身免疫中的潜在作用。
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2. **文献名称**: *GOLGA1 as a Biomarker in Colorectal Cancer: Expression Analysis Using Monoclonal Antibodies*
**作者**: Zhang L, et al.
**摘要**: 通过开发特异性GOLGA1单克隆抗体，研究揭示了结直肠癌组织中GOLGA1的异常高表达，表明其可能作为肿瘤进展的生物标志物，并参与癌细胞分泌途径的失调。
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3. **文献名称**: *HIV-1 Exploits the Golgi Apparatus for Viral Assembly: Insights from GOLGA1 Antibody Blocking Studies*
**作者**: Martinez O, et al.
**摘要**: 使用GOLGA1抗体阻断实验证明，HIV-1病毒颗粒的组装依赖于高尔基体相关蛋白GOLGA1.揭示其作为抗病毒治疗潜在靶点的可能性。
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4. **文献名称**: *Golgi Fragmentation in Neurodegeneration: Role of GOLGA1 Antibody in Detecting Early Changes*
**作者**: Chen H, et al.
**摘要**: 通过GOLGA1抗体标记高尔基体结构，研究发现阿尔茨海默病模型中高尔基体碎裂现象，提示GOLGA1可能成为神经退行性变的早期检测指标。
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注：以上文献为示例，实际引用时需核实具体文献来源及准确性。如需真实文献，建议通过PubMed或Google Scholar以关键词“GOLGA1 antibody”或“Golgin-1 autoantibody”检索。
GOLGA1 antibodies target the Golgin A1 protein, a member of the golgin family predominantly localized to the Golgi apparatus. Golgins are coiled-coil proteins crucial for maintaining Golgi structure, vesicle trafficking, and organelle positioning. GOLGA1. also known as Golgin-97. interacts with Rab6 GTPase and participates in retrograde transport from endosomes to the Golgi, ensuring proper protein sorting and glycosylation. It also stabilizes Golgi ribbons and mediates tethering of incoming transport vesicles.
Antibodies against GOLGA1 are widely used in cell biology to study Golgi morphology, intracellular trafficking, and Golgi-related pathologies. In clinical contexts, anti-GOLGA1 autoantibodies have been identified in certain autoimmune conditions, notably paraneoplastic neurological syndromes and some cancers, where they may serve as diagnostic biomarkers. Research also links GOLGA1 dysfunction to neurodegenerative diseases, as disrupted Golgi integrity impairs neuronal protein processing.
Commercially available GOLGA1 antibodies (polyclonal or monoclonal) are utilized in techniques like immunofluorescence, Western blotting, and immunohistochemistry. Specificity validation via knockout controls is essential due to structural similarities among golgins. Recent studies explore GOLGA1's role in viral infections (e.g., coronaviruses) that exploit Golgi machinery for replication, highlighting its broader biomedical relevance.
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