| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NET1; GLYT2; HKPX3; GLYT-2 |
| Entrez GeneID | 9152 |
| WB Predicted band size | Calculated MW: 87 kDa; Observed MW: 87 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human Glyt2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于GlyT2抗体的3篇参考文献，包含文献名称、作者及摘要内容的简要概括：
1. **文献名称**：*Glycine transporter 2 (GlyT2) mutations in compound heterozygous state cause neurological disease by impairing glycine release*
**作者**：Rees MI et al.
**摘要**：该研究揭示了GlyT2基因复合杂合突变导致糖原释放障碍，引发神经系统疾病(如高肌张力综合征)。研究利用特异性GlyT2抗体证实了突变对转运蛋白功能的影响，为相关疾病的分子机制提供了依据。
2. **文献名称**：*Autoantibodies to glycine receptors and GlyT2 in progressive encephalomyelitis with rigidity and myoclonus*
**作者**：Carvajal-González A et al.
**摘要**：本文报道了GlyT2自身抗体在僵人综合征(SPS)及其变异型患者中的发现，通过免疫组化和小脑颗粒细胞实验，证实了这些抗体可能通过干扰甘氨酸能传递导致肌肉强直和神经兴奋性异常。
3. **文献名称**：*Development of a selective antibody antagonist of glycine transporter 2 (GlyT2) with analgesic efficacy in neuropathic pain models*
**作者**：Nieto-Rostro M et al.
**摘要**：研究团队开发了一种高选择性GlyT2抗体拮抗剂，并在神经病理性疼痛模型中验证其镇痛效果。抗体通过阻断GlyT2功能增强脊髓甘氨酸水平，为慢性疼痛治疗提供了新策略。
注：若需获取具体发表年份或期刊信息，可进一步补充关键词检索(如疾病类型或应用场景)。
Glycine transporter 2 (GlyT2), encoded by the *SLC6A5* gene, is a sodium- and chloride-dependent neurotransmitter transporter primarily expressed in the presynaptic terminals of inhibitory glycinergic neurons in the spinal cord and brainstem. It plays a critical role in regulating synaptic glycine levels by recycling the neurotransmitter into presynaptic neurons, thereby terminating glycinergic signaling and maintaining inhibitory tone. Dysregulation of GlyT2 is implicated in hyperekplexia (startle disease), a rare neurological disorder characterized by excessive startle responses and muscle rigidity.
GlyT2 antibodies are autoantibodies targeting this transporter, first identified in rare autoimmune neurological syndromes. Recent studies associate GlyT2 antibodies with autoimmune brainstem encephalitis and cerebellar ataxia, where impaired glycinergic inhibition leads to motor dysfunction. These antibodies are thought to block GlyT2 function, reducing glycine reuptake and disrupting inhibitory neurotransmission. Detection methods include cell-based assays using HEK293 cells expressing human GlyT2. While their clinical significance is still being explored, GlyT2 antibodies represent a novel biomarker for autoimmune neurological conditions, expanding the spectrum of antibody-mediated CNS disorders. Research continues to clarify their pathogenic mechanisms and therapeutic implications, including potential benefits of immunotherapy in seropositive patients.
×
