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Rabbit Monoclonal GlycogenSynthase1 Antibody

  • 中文名： Glycogen Synthase 1抗体
  • 别    名： GYS1; GYS; Glycogen [starch] synthase; muscle
货号: IPDX21457
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGYS1; GYS; Glycogen [starch] synthase; muscle
Entrez GeneID2997
WB Predicted band sizeCalculated MW: 84 kDa; Observed MW: 84 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human Glycogen synthase 1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3条关于Glycogen Synthase 1(GYS1)抗体的模拟参考文献(内容为示例，非真实文献)：

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1. **文献名称**: "Glycogen Synthase 1 Antibody Validation in Skeletal Muscle Metabolism Studies"

**作者**: Smith J, et al.

**摘要**: 本研究通过Western blot和免疫组化验证了GYS1抗体的特异性，证明其在骨骼肌组织中可准确检测GYS1蛋白表达水平，并用于研究运动诱导的糖原合成调控机制。

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2. **文献名称**: "Role of GYS1 in Hepatocellular Carcinoma Progression: Insights from Antibody-based Profiling"

**作者**: Li X, et al.

**摘要**: 利用GYS1抗体分析肝癌组织样本，发现GYS1高表达与肿瘤糖代谢异常相关，提示其可能作为肝癌预后标志物和治疗靶点。

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3. **文献名称**: "Antibody-mediated Inhibition of Glycogen Synthase 1 Activity in Type 2 Diabetes Models"

**作者**: Kumar R, et al.

**摘要**: 通过特异性抗体阻断GYS1活性，研究其对胰岛素抵抗小鼠模型的影响，发现抑制GYS1可改善肝脏糖原过度积累，为糖尿病治疗提供新思路。

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(注：以上文献为模拟内容，如需真实文献，建议通过PubMed或Web of Science检索关键词"Glycogen Synthase 1 antibody"或"GYS1 antibody application"。)

背景信息

Glycogen Synthase 1 (GYS1) is a critical enzyme responsible for glycogen synthesis in various tissues, particularly skeletal muscle and liver. It catalyzes the transfer of glucose monomers from UDP-glucose to growing glycogen chains, a process essential for maintaining glucose homeostasis and energy storage. Dysregulation of GYS1 activity is linked to metabolic disorders, including type 2 diabetes, glycogen storage diseases (e.g., Pompe disease), and certain cancers. Antibodies targeting GYS1 are vital tools for studying its expression, regulation, and post-translational modifications (e.g., phosphorylation at specific serine residues) that modulate enzymatic activity. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate tissue-specific glycogen metabolism, insulin signaling pathways, and disease mechanisms. Research has also explored GYS1's role in cancer cell survival under hypoxic conditions, where glycogen accumulation supports tumor growth. Both monoclonal and polyclonal GYS1 antibodies are available, often validated for cross-reactivity across human, mouse, and rat models. Recent studies highlight GYS1 as a potential therapeutic target, driving demand for reliable antibodies to advance preclinical and clinical research in metabolic and oncological fields.

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