关键信息
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基因名
G3BP1
- 应用
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别名
(G3BP-1)(ATP-dependent DNA helicase VIII)(hDH VIII)(GAP SH3 domain-binding protein 1)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13283
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表达区间
1-466aa
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分子量
56.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
G3BP1, or GTPase-activating protein 1, is a crucial protein that plays an essential role in various cellular processes, including stress granule formation, viral replication, and regulation of gene expression. It is particularly significant in the context of the cellular stress response, where it facilitates the assembly of stress granules—cytoplasmic ribonucleoprotein complexes that sequester mRNAs and prevent their translation during unfavorable conditions. Given its involvement in key regulatory mechanisms, G3BP1 has attracted attention in both basic and applied research fields, especially in studies related to neurodegenerative diseases, cancer, and viral infections. The role of G3BP1 in mediating responses to cellular stress underscores its potential as a therapeutic target. Recent advancements in recombinant protein technology have enabled researchers to produce G3BP1 in vitro, allowing for detailed structural and functional analyses. By studying the characteristics and interactions of recombinant G3BP1, scientists aim to unravel its specific roles in cellular homeostasis and pathophysiology. Understanding G3BP1's mechanisms may lead to novel therapeutic approaches for diseases where cellular stress responses are disrupted.
