| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADF; AGEL; Brevin; Gelsolin; Gsn |
| Entrez GeneID | 2934 |
| WB Predicted band size | Calculated MW: 86 kDa; Observed MW: 86 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Gelsolin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Gelsolin抗体的参考文献概览(人工总结非真实文献，仅供参考格式)：
1. **文献名称**: "Gelsolin Antibody-Based Detection of Amyloid-β Aggregates in Alzheimer's Disease"
**作者**: Smith A, et al.
**摘要**: 该研究开发了针对gelsolin蛋白的特异性抗体，用于识别阿尔茨海默病患者脑组织中的β-淀粉样蛋白聚集体，证明gelsolin抗体可作为神经退行性疾病的潜在生物标志物检测工具。
2. **文献名称**: "Autoantibodies to Gelsolin in Rheumatoid Arthritis Patients"
**作者**: Chen L, et al.
**摘要**: 通过ELISA和免疫印迹技术，发现类风湿关节炎患者血清中存在gelsolin自身抗体，提示其可能参与自身免疫反应并作为疾病活动度的监测指标。
3. **文献名称**: "Therapeutic Targeting of Gelsolin in Cancer Metastasis Using Neutralizing Antibodies"
**作者**: Park JH, et al.
**摘要**: 研究团队制备了中和性gelsolin单克隆抗体，通过抑制gelsolin介导的细胞迁移和侵袭，显著降低乳腺癌小鼠模型的转移率，为抗肿瘤治疗提供新策略。
注：以上为示例性内容，实际文献需通过PubMed或Google Scholar检索关键词如“gelsolin antibody”、“therapeutic gelsolin”等获取。
Gelsolin is a multifunctional actin-binding protein that plays a critical role in regulating cytoskeletal dynamics by severing, capping, and nucleating actin filaments. It exists in two isoforms: cytoplasmic gelsolin (cGSN), involved in cell motility and morphology, and plasma gelsolin (pGSN), which circulates in bodily fluids to scavenge actin released during tissue injury. Gelsolin antibodies, either polyclonal or monoclonal, are essential tools for studying its expression, localization, and function in physiological and pathological contexts.
Dysregulation of gelsolin is linked to diseases such as amyloidosis (e.g., familial AGel amyloidosis caused by GSN gene mutations), inflammatory disorders, and cancer. In AGel amyloidosis, misfolded gelsolin fragments form toxic aggregates, driving tissue damage. Autoantibodies against gelsolin have also been identified in autoimmune conditions like rheumatoid arthritis, though their pathogenic role remains unclear.
Gelsolin antibodies are widely used in techniques like Western blotting, immunofluorescence, and ELISA to investigate its cleavage by proteases (e.g., caspase-3 during apoptosis) or interactions with partners like phosphoinositides. Recent studies explore gelsolin’s potential as a therapeutic target or biomarker, particularly in cancer metastasis and neurodegenerative diseases. However, challenges persist in standardizing antibody specificity across isoforms and understanding context-dependent roles in disease progression.
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