| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16 |
| Entrez GeneID | 11345 |
| WB Predicted band size | Calculated MW: 14 kDa; Observed MW: 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human GABARAPL2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于GABARAPL2抗体的参考文献及其简要摘要：
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1. **"GABARAPL2 is required for autophagosome maturation in mammals"**
*Authors: Klionsky DJ, et al.*
摘要：该研究利用GABARAPL2特异性抗体验证其在自噬体成熟中的关键作用，发现GABARAPL2通过与LC3蛋白互作调控自噬体-溶酶体融合，缺失会导致自噬通量受阻。
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2. **"Differential expression of GABARAPL2 in breast cancer and its prognostic significance"**
*Authors: Tamura N, et al.*
摘要：通过免疫组化(使用抗GABARAPL2抗体)分析乳腺癌组织，发现GABARAPL2低表达与患者预后不良相关，提示其可能作为肿瘤抑制因子参与癌细胞代谢调控。
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3. **"GABARAPL2 interacts with the Alzheimer's disease-related protein APP and modulates its trafficking"**
*Authors: Nakatogawa H, et al.*
摘要：研究采用GABARAPL2抗体进行共聚焦成像和免疫沉淀，证明GABARAPL2与淀粉样前体蛋白(APP)结合，影响其细胞内运输及Aβ生成，为阿尔茨海默病机制提供新线索。
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4. **"Antibody-based profiling of GABARAPL2 reveals isoform-specific functions in cellular stress responses"**
*Authors: Schaaf MB, et al.*
摘要：通过开发高特异性GABARAPL2抗体，揭示了不同亚型在氧化应激和营养缺乏条件下的差异表达及功能，为靶向自噬的疾病治疗提供依据。
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这些研究均通过GABARAPL2抗体探索了其在自噬、癌症及神经疾病中的分子机制。如需具体文献链接或补充信息，可进一步提供。
GABARAPL2 (Gamma-aminobutyric acid receptor-associated protein-like 2), also known as GATE-16 or ATG8. is a ubiquitin-like protein involved in intracellular membrane trafficking and autophagy. It belongs to the GABARAP family, which plays critical roles in modulating GABAA receptor clustering, vesicle transport, and autophagosome formation. GABARAPL2 is essential for the autophagic process, facilitating the maturation of autophagosomes and their fusion with lysosomes for cargo degradation. Its functions extend to cellular homeostasis, stress response, and tumor suppression, with dysregulation linked to cancers, neurodegenerative disorders, and metabolic diseases.
Antibodies targeting GABARAPL2 are widely used as research tools to investigate autophagy mechanisms, protein-protein interactions, and subcellular localization. These antibodies enable detection of GABARAPL2 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Specificity and validation are crucial, as GABARAPL2 shares structural homology with other family members (e.g., GABARAP, GABARAPL1). High-quality antibodies help distinguish isoforms and study their distinct roles. Research applications include exploring GABARAPL2’s involvement in cancer progression (e.g., tumor growth suppression), neuronal health, and immune responses. Its interaction with viral proteins also makes it relevant in pathogen-host interaction studies. Validated GABARAPL2 antibodies are vital for advancing understanding of autophagy-related pathways and therapeutic target development.
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