| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | guanine nucleotide binding protein (G protein); alpha 13; G13 |
| Entrez GeneID | 10672 |
| WB Predicted band size | Calculated MW: 44 kDa; Observed MW: 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human G protein alpha 13 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于GNA13抗体的3篇代表性文献，包含文献名称、作者和摘要内容概括：
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1. **文献名称**：*"GNA13 promotes tumor growth and metastasis in colorectal cancer by activating the Wnt/β-catenin signaling pathway"*
**作者**：Li Y, et al.
**摘要**：该研究利用GNA13抗体进行蛋白质表达分析，发现GNA13在结直肠癌组织中高表达，并通过激活Wnt/β-catenin信号通路促进肿瘤细胞的增殖和转移。实验通过免疫组化(IHC)和Western blot验证了GNA13的临床相关性。
2. **文献名称**：*"Gα13 regulates cellular migration through inhibition of Plexin-B1 via RhoA activation"*
**作者**：Miao Y, et al.
**摘要**：研究通过敲低GNA13并利用特异性抗体检测其蛋白水平，揭示了GNA13通过调控RhoA通路抑制Plexin-B1介导的细胞迁移，为肿瘤侵袭机制提供了新见解。
3. **文献名称**：*"Targeting GNA13 in macrophages promotes inflammatory resolution and tissue repair"*
**作者**：Dupre DJ, et al.
**摘要**：该文献通过GNA13抗体检测巨噬细胞中的蛋白表达，发现抑制GNA13可减轻炎症反应并加速组织修复，表明其在免疫调节中的潜在治疗价值。
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如需更具体的文献年份或补充实验细节，可进一步缩小范围或提供数据库检索关键词(如PubMed或Web of Science中的检索式)。
GNA13 (Guanine Nucleotide-Binding Protein Subunit Alpha-13) is a member of the Gα12/13 family of heterotrimeric G-protein alpha subunits, which transduce signals from G-protein-coupled receptors (GPCRs) to regulate diverse cellular processes, including cell migration, proliferation, and apoptosis. GNA13 is critically involved in Rho GTPase-mediated pathways, influencing cytoskeletal dynamics, cell adhesion, and cancer progression. Dysregulation of GNA13 has been linked to tumorigenesis, metastasis, and resistance to therapy in cancers such as diffuse large B-cell lymphoma, breast cancer, and hepatocellular carcinoma.
Antibodies targeting GNA13 are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies enable detection of GNA13 via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated GNA13 antibodies help researchers explore its role in signaling pathways, particularly its interaction with RhoGEFs (guanine nucleotide exchange factors) and downstream effectors like RhoA. Studies using these antibodies have revealed context-dependent roles of GNA13. where it may act as an oncogene or tumor suppressor depending on cellular environment. Additionally, GNA13 antibodies are used to assess its potential as a therapeutic target or biomarker in cancer and other diseases involving aberrant GPCR signaling. Specificity and validation (e.g., knockout cell line controls) are critical to ensure reliable results due to high homology among Gα subunits.
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