| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADAP; Fyb; FYN binding protein; p120/p130; SLAP130 |
| Entrez GeneID | 2533 |
| WB Predicted band size | Calculated MW: 85 kDa; Observed MW: 130,120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human FYB |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于FYB抗体的3篇示例参考文献(注：内容为模拟示例，实际文献请查阅数据库)：
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1. **文献名称**: *Fyb/SLAP-130 regulates T cell receptor-mediated integrin activation through adhesion and degranulation-promoting adaptor protein*
**作者**: Peterson EJ, et al.
**摘要**: 研究揭示了FYB(又称SLAP-130)在T细胞受体(TCR)信号传导中的关键作用，通过调控整合素活化促进免疫突触形成。实验使用FYB特异性抗体进行免疫沉淀，发现其与ADAP蛋白相互作用，影响T细胞黏附和激活。
2. **文献名称**: *Role of Fyb in platelet function and thrombus stability*
**作者**: Obergfell A, et al.
**摘要**: 通过FYB抗体阻断实验，证明FYB在血小板信号通路中调控细胞骨架重组，影响血小板聚集和血栓稳定性。基因敲除小鼠模型显示FYB缺陷导致出血时间延长。
3. **文献名称**: *Structural insights into Fyb protein interactions using monoclonal antibodies*
**作者**: Smith ML, et al.
**摘要**: 报道了针对FYB不同表位的单克隆抗体的开发，通过X射线晶体学解析FYB与抗体复合物结构，揭示了其与下游效应分子(如SKAP1)的结合位点，为靶向免疫疾病的治疗提供依据。
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如需实际文献，建议通过PubMed或Google Scholar检索关键词“FYB antibody”、“Fyb/SLAP-130”或“Fyb T cell”。
FYB (FYN-binding protein), also known as ADAP (Adhesion and Degranulation Promoting Adaptor Protein), is a cytoplasmic adaptor protein predominantly expressed in immune cells, particularly T cells and platelets. It plays a critical role in regulating immune cell activation, adhesion, and signaling. FYB interacts with FYN, a Src-family kinase, and other signaling molecules like SKAP1. facilitating the assembly of multiprotein complexes involved in T-cell receptor (TCR) signaling and integrin activation. This interaction is essential for immunological synapse formation, cytokine secretion, and cytoskeletal reorganization during immune responses.
FYB antibodies are valuable tools in immunology research, enabling the detection and functional analysis of FYB protein expression, localization, and interactions. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to study T-cell activation mechanisms, platelet function, and inflammation-related pathways. Dysregulation of FYB has been implicated in autoimmune diseases, chronic inflammation, and platelet disorders, making its study relevant for therapeutic targeting. Research using FYB antibodies has contributed to understanding how adaptor proteins coordinate signaling networks in health and disease, offering insights into potential interventions for immune dysregulation.
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