| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DNA helicase V; FBP; FUBP; Fubp1; Fubp4; FUSE-binding protein 1; HDH V |
| Entrez GeneID | 8880 |
| WB Predicted band size | Calculated MW: 68 kDa; Observed MW: 74 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human FUBP1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于FUBP1抗体的虚构参考文献示例(仅供参考，非真实文献)：
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1. **文献名称**：FUBP1 overexpression in glioblastoma correlates with poor prognosis via c-Myc activation
**作者**：Vo TN, et al.
**摘要**：本研究通过免疫组化(使用FUBP1特异性抗体)分析了胶质瘤患者肿瘤组织中FUBP1的表达水平，发现其高表达与c-Myc信号通路激活及患者预后不良显著相关，提示FUBP1可能作为治疗靶点。
2. **文献名称**：FUBP1 regulates DNA damage response through interaction with ATM kinase
**作者**：Duncan R, et al.
**摘要**：利用FUBP1抗体进行免疫共沉淀和Western blot实验，揭示了FUBP1通过结合ATM激酶调控DNA损伤修复机制，其缺失导致细胞对辐射敏感性增加。
3. **文献名称**：Loss of FUBP1 disrupts neuronal differentiation in vitro
**作者**：Kramer P, et al.
**摘要**：通过shRNA敲低FUBP1并结合抗体检测蛋白表达，研究发现FUBP1缺失会干扰神经干细胞分化，表明其在神经发育中的关键作用。
4. **文献名称**：FUBP1 mutations alter chromatin binding in hematologic malignancies
**作者**：Zhang Y, et al.
**摘要**：采用ChIP-seq(FUBP1抗体)和测序技术，发现血液系统恶性肿瘤中FUBP1突变导致其染色质结合能力下降，进而影响靶基因转录调控。
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如需真实文献，建议通过PubMed或Google Scholar以“FUBP1 antibody”或“FUBP1 function”为关键词检索近年研究。
FUBP1 (Far Upstream Element Binding Protein 1) is a DNA/RNA-binding protein involved in regulating gene expression, particularly through interactions with the far upstream element (FUSE) of target genes like the proto-oncogene MYC. It functions as a transcriptional activator or repressor, depending on cellular context, and plays roles in cell proliferation, apoptosis, and DNA repair. Dysregulation of FUBP1 has been linked to cancers, including gliomas, hepatocellular carcinoma, and lung cancer, where its overexpression or mutation correlates with tumor progression and poor prognosis.
FUBP1 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate FUBP1’s role in oncogenesis, RNA metabolism, and cellular stress responses. Researchers also utilize them to explore FUBP1’s involvement in neurological disorders, as aberrant FUBP1 activity has been associated with conditions like frontotemporal dementia.
Commercially available FUBP1 antibodies are typically raised against specific epitopes within the protein’s functional domains, such as its N-terminal regulatory region or C-terminal DNA-binding domain. Validation across applications and species is critical, as off-target reactivity may occur. Ongoing studies continue to clarify FUBP1’s dual roles in health and disease, underscoring the importance of reliable antibodies in both basic research and clinical diagnostics.
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