| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FPS |
| Entrez GeneID | 2242 |
| WB Predicted band size | Calculated MW: 93 kDa; Observed MW: 93 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human FES |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3条关于FES抗体的模拟参考文献示例(基于常见研究主题构造)：
1. **文献名称**：*Production and characterization of monoclonal antibodies against the FES tyrosine kinase*
**作者**：Smith, J.R., et al.
**摘要**：研究报道了针对FES酪氨酸激酶单克隆抗体的开发，验证了抗体在免疫印迹和免疫沉淀中的特异性，并应用于检测FES在白血病细胞中的表达水平。
2. **文献名称**：*FES oncogene signaling in myeloid differentiation: Insights from antibody-based inhibition studies*
**作者**：Lee, H., & Brown, M.T.
**摘要**：通过使用FES特异性中和抗体，研究揭示了FES激酶在髓系细胞分化中的作用，证明其通过调控STAT3信号通路影响细胞分化进程。
3. **文献名称**：*Immunohistochemical detection of FES protein in solid tumors using a novel polyclonal antibody*
**作者**：Garcia, S., et al.
**摘要**：开发了一种新型多克隆抗体，用于免疫组化检测多种实体瘤中FES蛋白的异常表达，发现其与肿瘤侵袭性相关，提示潜在临床价值。
(注：以上文献为示例性构造，实际引用需根据具体文献调整。)
**Background of FES Antibodies**
The FES (feline sarcoma oncogene) protein, encoded by the *fps/fes* proto-oncogene, is a non-receptor tyrosine kinase involved in regulating cellular signaling pathways. Initially identified in retroviral oncogenes (v-Fes), it plays roles in cell differentiation, proliferation, and immune response. FES is expressed in hematopoietic, endothelial, and epithelial cells, where it modulates cytoskeletal dynamics and signal transduction through interactions with cytokines, growth factors, and adhesion molecules.
FES antibodies are critical tools for studying its expression, activation, and functional roles in both normal and pathological contexts. Research highlights FES's dual role: it can act as a tumor suppressor in myeloid leukemias by promoting differentiation, yet exhibit oncogenic potential in solid tumors via hyperactivation. Dysregulation of FES is linked to cancers, inflammation, and vascular diseases.
Antibodies targeting FES enable detection of protein levels, phosphorylation status (e.g., Tyr phosphorylation sites), and subcellular localization using techniques like Western blot, immunohistochemistry, and flow cytometry. They also aid in exploring therapeutic strategies, such as kinase inhibition. Recent studies focus on FES's interaction with signaling hubs like PI3K/AKT and MAPK pathways, offering insights into its context-dependent roles.
Overall, FES antibodies are vital for unraveling the protein's complex biology and its implications in disease mechanisms and targeted therapies.
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