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Rabbit Monoclonal KDM2A Antibody

  • 中文名: KDM2A抗体
  • 别    名: FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
货号: IPDX21384
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
Entrez GeneID22992
WB Predicted band sizeCalculated MW: 133 kDa; Observed MW: 133 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human FBXL11
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于KDM2A抗体的3篇参考文献示例(文献名称和作者为虚构,内容基于典型研究方向概括):

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1. **"KDM2A regulates ribosomal RNA transcription through H3K36 demethylation"**

*作者:Li X, Zhang Y, et al.*

**摘要**:本研究利用KDM2A特异性抗体进行染色质免疫沉淀(ChIP),揭示了KDM2A通过去除核糖体DNA区域的H3K36me2标记抑制rRNA转录,表明其在调控核糖体生物发生中的关键作用。

2. **"KDM2A antibody-based profiling identifies its overexpression in lung adenocarcinoma"**

*作者:Wang H, Chen J, et al.*

**摘要**:通过Western blot和免疫组化(IHC)分析,发现KDM2A在肺癌组织中高表达,且与患者预后不良相关,提示其可能作为癌症治疗的潜在靶点。

3. **"Epigenetic silencing of tumor suppressors by KDM2A in pancreatic cancer"**

*作者:Kim S, Patel R, et al.*

**摘要**:研究使用KDM2A抗体验证其在胰腺癌细胞系中的表达,证明KDM2A通过去甲基化修饰促进抑癌基因启动子区域的异染色质形成,从而驱动肿瘤发生。

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(注:以上文献信息为示例,实际引用需检索PubMed等数据库获取真实文献。)

背景信息

The KDM2A antibody is a crucial tool for studying the lysine-specific demethylase 2A (KDM2A), also known as FBXL11 or JHDM1A. KDM2A belongs to the JmjC domain-containing histone demethylase family and plays a significant role in epigenetic regulation by catalyzing the removal of methyl groups from histone H3 lysine 36 (H3K36me1/me2). This enzyme is involved in diverse cellular processes, including transcriptional repression, heterochromatin formation, and maintenance of genomic stability. KDM2A also interacts with polycomb repressive complexes and regulates developmental genes, stem cell differentiation, and cellular senescence. Dysregulation of KDM2A has been linked to cancer, metabolic disorders, and aging-related diseases. Researchers use KDM2A antibodies in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry to investigate its expression, localization, and functional mechanisms. These antibodies aid in exploring KDM2A's role in modulating chromatin structure, gene expression networks, and its potential as a therapeutic target. Validating antibody specificity through knockout controls or siRNA knockdown is essential due to homology with related demethylases like KDM2B.

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