| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein FAM98B |
| Entrez GeneID | 283742 |
| WB Predicted band size | Calculated MW: 46 kDa; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human FAM98B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于FAM98B抗体的模拟参考文献示例(注：因文献检索限制，以下为假设性示例，建议通过PubMed或Google Scholar验证真实文献)：
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1. **文献名称**: "FAM98B regulates cell migration through microtubule stabilization"
**作者**: Zhang L, et al.
**摘要**: 本研究利用FAM98B特异性抗体探究其在细胞迁移中的作用，发现FAM98B通过与微管结合蛋白相互作用调控细胞骨架动力学，敲低FAM98B导致细胞迁移能力显著下降。
2. **文献名称**: "Characterization of a novel monoclonal antibody against human FAM98B for cancer research"
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种新型FAM98B单克隆抗体的开发与验证，该抗体在免疫印迹和免疫荧光中表现出高特异性，并用于检测多种癌细胞系中FAM98B的异常表达。
3. **文献名称**: "FAM98B interacts with RNA-binding proteins and modulates RNA localization in neurons"
**作者**: Smith J, et al.
**摘要**: 通过免疫共沉淀(使用FAM98B抗体)结合质谱分析，揭示了FAM98B在神经元RNA转运中的功能，其缺失导致突触蛋白合成障碍。
4. **文献名称**: "FAM98B antibody reveals its overexpression in colorectal cancer tissues"
**作者**: Wang Y, et al.
**摘要**: 利用组织芯片和FAM98B抗体进行免疫组化分析，发现FAM98B在结直肠癌组织中高表达，并与患者预后不良相关。
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建议通过 **PubMed** 或 **Web of Science** 搜索关键词 "FAM98B antibody" 获取真实文献。
FAM98B (Family with sequence similarity 98 member B) is a relatively understudied protein encoded by the FAM98B gene in humans. It belongs to the FAM98 family, which includes FAM98A and FAM98C, all sharing conserved N-terminal domains. While its precise molecular functions remain unclear, emerging studies suggest FAM98B participates in cellular processes such as RNA metabolism, protein-protein interactions, and microtubule network organization. It is hypothesized to act as a scaffolding protein, potentially forming complexes with other proteins like NuMA (nuclear mitotic apparatus protein) or CEP170 (centrosomal protein 170) to regulate cytoskeletal dynamics or cell cycle progression.
FAM98B antibodies are primarily used as research tools to investigate the protein's expression, localization, and functional roles. Immunohistochemical studies reveal its cytoplasmic localization, with enriched expression in tissues like the brain, testis, and gastrointestinal tract. Recent research links FAM98B dysregulation to pathological conditions, including colorectal cancer and breast cancer, where it may influence tumor cell proliferation and migration. Commercial FAM98B antibodies (polyclonal or monoclonal) are typically validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation. However, antibody specificity remains a challenge due to potential cross-reactivity with homologous family members. Ongoing studies aim to clarify its molecular mechanisms and therapeutic potential in disease contexts.
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