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Rabbit Monoclonal XPO4 Antibody

  • 中文名： XPO4抗体
  • 别    名： exp4
货号: IPDX21371
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesexp4
Entrez GeneID64328
WB Predicted band sizeCalculated MW: 130 kDa; Observed MW: 130 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human Exportin 4
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于XPO4抗体的代表性文献示例(内容基于学术文献框架模拟，实际引用请核实原文)：

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1. **文献名称**：*XPO4-mediated nuclear export of Smad3 promotes TGF-β signaling and tumor metastasis*

**作者**：Wang Y, et al.

**摘要**：研究揭示了XPO4(Exportin-4)通过介导Smad3蛋白的核输出调控TGF-β信号通路，促进肿瘤转移。实验中使用XPO4特异性抗体进行免疫共沉淀(Co-IP)和免疫荧光染色，证实XPO4在乳腺癌细胞中的高表达与患者预后不良相关。

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2. **文献名称**：*Exportin-4 interacts with the tumor suppressor p53 and regulates its subcellular localization*

**作者**：Li J, et al.

**摘要**：该文献发现XPO4通过直接结合p53蛋白调控其核质穿梭，影响p53的抑癌功能。研究利用XPO4抗体进行Western blot和免疫组化分析，发现XPO4在结肠癌组织中表达上调，并可能通过抑制p53活性促进肿瘤发展。

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3. **文献名称**：*XPO4 as a potential biomarker for drug resistance in hepatocellular carcinoma*

**作者**：Chen H, et al.

**摘要**：通过构建肝癌细胞模型，研究证明XPO4高表达与化疗耐药性相关。使用XPO4抗体进行流式细胞术和免疫沉淀实验，发现抑制XPO4可增强顺铂对肝癌细胞的杀伤效果，提示XPO4可能成为耐药治疗的靶点。

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如需具体文献全文或DOI号，建议在PubMed或Google Scholar中检索关键词(如"XPO4 antibody" + "cancer"/"mechanism")。

背景信息

The XPO4 antibody is a research tool designed to detect Exportin-4 (XPO4), a member of the karyopherin-β nuclear transport receptor family. XPO4 facilitates the nuclear export of specific cargo proteins and RNAs, playing a role in regulating cellular processes such as gene expression, RNA metabolism, and protein localization. Unlike its well-studied homolog XPO1 (CRM1), which exports proteins containing a leucine-rich nuclear export signal (NES), XPO4 is implicated in transporting distinct substrates, including the tumor suppressor protein Smad3 in the TGF-β signaling pathway. This function links XPO4 to pathways involved in cell growth, differentiation, and cancer progression. Research suggests XPO4 may act as a tumor suppressor in certain contexts, as its dysregulation has been observed in malignancies like hepatocellular carcinoma. Antibodies against XPO4 are used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in cellular and disease models. These studies aim to clarify XPO4's mechanistic roles and therapeutic potential, particularly in oncology and cellular transport biology.

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