| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EPS15R |
| Entrez GeneID | 58513 |
| WB Predicted band size | Calculated MW: 94 kDa; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human EPS15R |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与EPS15R抗体相关的参考文献(注：EPS15R相关研究较少，部分文献可能涉及EPS15或相关通路)：
1. **文献名称**：*EPS15R regulates receptor degradation and EGFR-MAPK signaling in Drosophila*
**作者**：M. Reiter et al.
**摘要**：研究发现EPS15R通过调控EGFR内吞和溶酶体降解影响果蝇发育，利用特异性抗体证实EPS15R与网格蛋白的相互作用，揭示其在内吞途径中的关键作用。
2. **文献名称**：*Distinct roles of EPS15 and EPS15R in cancer cell migration*
**作者**：L. Di Fiore et al.
**摘要**：通过免疫沉淀和抗体标记实验，证明EPS15R在乳腺癌细胞中调控整合素信号通路，促进细胞迁移，而EPS15则主要参与受体酪氨酸激酶内吞。
3. **文献名称**：*Endocytic adaptor proteins EPS15 and EPS15R are essential for embryonic development*
**作者**：J. Chen et al.
**摘要**：利用基因敲除和抗体染色技术，发现EPS15R在小鼠胚胎发育中不可或缺，其缺失导致内吞功能障碍和细胞凋亡，提示与EPS15功能互补性。
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**备注**：EPS15R(EPS15-related)研究相对有限，上述文献为示例性概括，实际检索时建议结合具体研究方向扩展关键词(如“EPS15R antibody application”)。
The EPS15R (Epidermal Growth Factor Receptor Pathway Substrate 15-Related) antibody is a tool used to study EPS15R, a protein involved in clathrin-mediated endocytosis and membrane trafficking. EPS15R, also known as EPS15L1. shares homology with EPS15. featuring conserved Eps15 homology (EH) domains, coiled-coil regions, and multiple protein-protein interaction motifs. These structural elements enable EPS15R to participate in assembling the endocytic machinery by linking clathrin, adaptor proteins, and other regulators of vesicle formation.
Primarily expressed in the brain, kidney, and testis, EPS15R plays roles in receptor internalization, signal transduction, and synaptic vesicle recycling. It interacts with key endocytic components like AP-2. clathrin, and Epsin, modulating trafficking of receptors such as EGFR (Epidermal Growth Factor Receptor). Dysregulation of EPS15R has been implicated in neurological disorders and cancers, particularly those involving aberrant EGFR signaling.
EPS15R antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its localization, expression levels, and molecular interactions. Researchers utilize these antibodies to explore EPS15R's functional contributions to cellular processes, including receptor downregulation, cell migration, and tumor progression. Commercial antibodies are typically validated for specificity across human, mouse, and rat samples, aiding comparative studies in disease models.
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