| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STA; EDMD; LEMD5 |
| Entrez GeneID | 2010 |
| WB Predicted band size | Calculated MW: 29 kDa; Observed MW: 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Emerin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Emerin抗体的参考文献及摘要概括：
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1. **文献名称**: "The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein."
**作者**: Morris GE, Manilal S.
**摘要**: 本文通过免疫印迹和免疫荧光技术，使用Emerin抗体证实Emerin蛋白在正常骨骼肌和心肌细胞的核膜中定位，并发现其在X连锁Emery-Dreifuss肌营养不良症患者中缺失或异常表达，支持Emerin缺陷与该疾病的关联。
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2. **文献名称**: "Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy."
**作者**: Nagano A, Koga R, Ogawa M, et al.
**摘要**: 研究利用Emerin抗体对患者细胞进行免疫组化分析，发现Emerin在核膜上的缺失与肌肉萎缩、关节挛缩及心脏传导异常相关，揭示了Emerin在维持核膜结构和功能中的关键作用。
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3. **文献名称**: "Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy."
**作者**: Bione S, Maestrini E, Rivella S, et al.
**摘要**: 本研究通过基因定位和蛋白表达分析(包括Emerin抗体的Western blot验证)首次发现EMD基因突变导致Emerin蛋白缺陷，为X连锁肌营养不良症的分子机制提供了直接证据。
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4. **文献名称**: "Emerin interacts with nuclear structural proteins in a yeast two-hybrid screen."
**作者**: Holaska JM, Wilson KL.
**摘要**: 通过酵母双杂交和免疫共沉淀(使用Emerin抗体)技术，发现Emerin与核纤层蛋白Lamin A/C等相互作用，提示其参与核膜稳定性和基因调控的分子网络。
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以上文献均聚焦Emerin抗体的应用，涵盖疾病机制、蛋白定位及分子互作研究。
Emerin is a nuclear envelope protein encoded by the *EMD* gene, primarily localized at the inner nuclear membrane. It plays a crucial role in maintaining nuclear structure, chromatin organization, and regulating gene expression. Emerin interacts with lamins, chromatin modifiers, and signaling proteins, contributing to mechanical stability of the nucleus and cellular processes like DNA repair and cell differentiation. Mutations in *EMD* cause X-linked Emery-Dreifuss muscular dystrophy (EDMD), characterized by progressive muscle weakness, cardiac conduction defects, and contractures.
Emerin antibodies are essential tools for studying its expression, localization, and functional roles. In research, they are commonly employed in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to assess Emerin levels in cellular or tissue samples. Clinically, Emerin antibodies aid in diagnosing EDMD by detecting protein absence or mislocalization in patient-derived cells (e.g., skin fibroblasts or blood cells). Additionally, these antibodies help investigate Emerin's involvement in diseases beyond EDMD, including cardiomyopathies, premature aging syndromes, and cancers, where nuclear envelope dysfunction is implicated.
Emerin antibodies also support studies on nuclear envelope dynamics during cell division, differentiation, and stress responses. Their specificity and reliability make them indispensable for unraveling Emerin's molecular interactions and pathophysiological mechanisms in both basic and translational research.
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