| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280 |
| WB Predicted band size | 281 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FLNA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于E1B AP5抗体的假想参考文献示例(注：实际文献可能需要通过学术数据库验证，以下内容为示例性概括)：
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1. **文献名称**: "E1B-AP5 Antibody Characterization in Adenovirus-Mediated Apoptosis Inhibition"
**作者**: Smith J, et al.
**摘要**: 本研究利用E1B AP5抗体探究腺病毒E1B蛋白与宿主AP5蛋白的相互作用，发现E1B通过结合AP5抑制线粒体途径的细胞凋亡，从而促进病毒复制。抗体特异性验证显示其对E1B-AP5复合物具有高亲和力。
2. **文献名称**: "Role of E1B-AP5 Complex in Viral Oncolysis and Cancer Therapy"
**作者**: Lee H, et al.
**摘要**: 通过E1B AP5抗体检测发现，腺病毒E1B蛋白与AP5的结合可阻断肿瘤细胞中p53信号通路，增强溶瘤病毒的抗癌效果。研究为靶向E1B-AP5的癌症治疗策略提供了实验依据。
3. **文献名称**: "Development of a Monoclonal Antibody Targeting E1B-AP5 for Diagnostic Applications"
**作者**: Garcia R, et al.
**摘要**: 报道了一种新型E1B AP5单克隆抗体的开发，该抗体在免疫组化中特异性识别病毒感染的细胞，适用于腺病毒相关疾病的病理学诊断和机制研究。
4. **文献名称**: "E1B-AP5 Interaction Regulates Autophagy in Virus-Infected Cells"
**作者**: Chen L, et al.
**摘要**: 利用E1B AP5抗体揭示腺病毒E1B蛋白通过结合AP5调控宿主细胞自噬过程，抑制自噬体形成以维持病毒存活。研究为病毒-宿主互作机制提供了新见解。
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**提示**：以上为示例性内容，实际文献需通过PubMed、Web of Science等平台检索关键词(如"E1B AP5 antibody"、"E1B-AP5 complex")。若研究领域较为小众，建议结合具体研究背景(如腺病毒、凋亡、癌症治疗)扩大检索范围。
The E1B-AP5 antibody targets the E1B-AP5 protein, a cellular factor initially identified through its interaction with the adenovirus E1B-55kDa oncoprotein. E1B-AP5. also known as heterogeneous nuclear ribonucleoprotein U-like 2 (HNRNPUL2), is a RNA-binding protein involved in mRNA metabolism, including splicing, transport, and stability. It belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays roles in post-transcriptional gene regulation. The E1B-AP5/E1B-55kDa complex is critical for adenovirus replication, facilitating viral mRNA export and host cell shutoff.
Studies using the E1B-AP5 antibody have elucidated its role in viral pathogenesis and cellular processes. The antibody aids in detecting E1B-AP5 expression in immunoprecipitation, Western blotting, or immunofluorescence, helping researchers study its interaction with viral proteins and its involvement in stress responses, DNA repair, and apoptosis. Dysregulation of E1B-AP5 has been implicated in cancer, as altered RNA metabolism contributes to tumor progression.
This antibody is a tool for exploring virus-host interactions, RNA biology, and oncogenic mechanisms, bridging virology and cancer research. Its applications extend to understanding how viral proteins co-opt cellular machinery, providing insights into therapeutic targets for viral infections or malignancies.
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