| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MST104; MSTP104; PRO1472 |
| Entrez GeneID | 55466 |
| WB Predicted band size | Calculated MW: 45 kDa; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human DNAJA4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于DNAJA4抗体的假设性参考文献示例，供参考(建议通过学术数据库验证具体文献)：
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1. **文献名称**：*DNAJA4 as a novel biomarker for oxidative stress in Alzheimer's disease*
**作者**：Chen L, et al. (2021)
**摘要**：本研究利用DNAJA4抗体检测阿尔茨海默病患者脑组织中的蛋白表达，发现DNAJA4在氧化应激相关神经元损伤中显著上调，提示其可能参与疾病进展中的蛋白质质量控制机制。
2. **文献名称**：*Characterization of a monoclonal antibody against human DNAJA4 and its application in cancer prognosis*
**作者**：Wang Y, et al. (2019)
**摘要**：作者开发了一种高特异性DNAJA4单克隆抗体，并通过免疫组化分析其在肺癌组织中的表达，发现DNAJA4高表达与患者生存率降低相关，可能作为癌症预后的潜在标志物。
3. **文献名称**：*DNAJA4 regulates thermotolerance by modulating HSP70 activity in Drosophila*
**作者**：Rodriguez S, et al. (2017)
**摘要**：通过RNA干扰和DNAJA4抗体免疫印迹实验，揭示了DNAJA4在果蝇热应激反应中对HSP70分子伴侣功能的调控作用，证实其对耐热性的关键影响。
4. **文献名称**：*Tissue-specific expression profiling of DNAJA4 in murine models of metabolic syndrome*
**作者**：Kumar R, et al. (2020)
**摘要**：使用DNAJA4抗体对代谢综合征小鼠模型进行组织分析，发现肝脏和脂肪组织中DNAJA4表达异常，可能与胰岛素抵抗中的内质网应激反应相关。
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**注意**：以上文献为示例性内容，实际引用需通过PubMed、Web of Science等平台核实。研究DNAJA4抗体时，建议关注其应用场景(如疾病模型、分子机制)及抗体来源(如商业化抗体的品牌及验证数据)。
DNAJA4 antibody targets the DNAJA4 protein, a member of the Hsp40 (DnaJ) family of molecular chaperones. DNAJA4. also known as Hsp40 homolog subfamily A member 4. plays a regulatory role in the Hsp70 chaperone system by stimulating ATPase activity and directing substrate specificity. It is involved in protein folding, degradation, and stress response pathways, particularly under cellular stress conditions like heat shock or oxidative damage. DNAJA4 is expressed in various tissues, with higher levels observed in the brain, testis, and certain cancers, suggesting potential roles in neuroprotection, reproduction, and tumorigenesis.
The DNAJA4 antibody is widely used in research to detect and quantify DNAJA4 expression in experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. It aids in studying DNAJA4's interaction with Hsp70. its subcellular localization (primarily cytoplasmic), and its involvement in diseases such as neurodegenerative disorders (e.g., Alzheimer’s) and cancers (e.g., glioblastoma, breast cancer). Commercial DNAJA4 antibodies are typically developed in hosts like rabbits or mice, with validation across multiple applications. Its utility extends to exploring stress adaptation mechanisms, protein quality control, and therapeutic targeting of chaperone networks in pathological conditions.
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