| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SPF31; HSPC331 |
| Entrez GeneID | 22826 |
| WB Predicted band size | Calculated MW: 30 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Immunogen | A synthetic peptide of human DjC8 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3条关于DNAJC8抗体的虚构参考文献示例(基于领域知识合理推测，非真实文献)：
---
1. **文献名称**: *DNAJC8 interacts with tau protein in Alzheimer's disease models*
**作者**: Chen L, et al.
**摘要**: 本研究利用特异性DNAJC8抗体进行免疫共沉淀，发现DNAJC8与磷酸化tau蛋白在阿尔茨海默病小鼠脑组织中存在直接相互作用，提示其可能参与tau病理调控。
2. **文献名称**: *DNAJC8 antibody validation for cancer biomarker screening*
**作者**: Gupta R, et al.
**摘要**: 报道了一种高特异性DNAJC8单克隆抗体的开发，通过免疫组化验证其在结直肠癌组织中的表达上调，并证明其与患者预后不良相关。
3. **文献名称**: *DNAJC8 regulates HSF1 activation under heat shock stress*
**作者**: Park S, et al.
**摘要**: 利用DNAJC8抗体进行蛋白质互作分析，揭示了DNAJC8通过结合热休克因子1(HSF1)调控热应激反应，并影响HSP70伴侣系统的激活机制。
---
注：以上文献为模拟生成，实际研究中建议通过PubMed或Web of Science检索真实文献。
The DNAJC8 antibody targets the DNAJC8 protein, a member of the HSP40/DnaJ family, which functions as a co-chaperone to regulate HSP70 activity. DNAJC8 is involved in protein folding, quality control, and stress response pathways. It contains a conserved J-domain that interacts with HSP70 ATPase, facilitating substrate binding and ATP hydrolysis. DNAJC8 also participates in diverse cellular processes, including transcriptional regulation, apoptosis, and DNA repair, by modulating chaperone-mediated protein trafficking and complex assembly.
Antibodies against DNAJC8 are essential tools for studying its expression, localization, and interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to explore DNAJC8’s role in physiological and pathological contexts. Dysregulation of DNAJC8 has been implicated in cancers, neurodegenerative diseases, and metabolic disorders, making it a potential biomarker or therapeutic target. Commercial DNAJC8 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptide or recombinant protein antigens. Validation includes specificity tests (e.g., knockout controls) and functional assays. Researchers prioritize antibodies with high affinity, minimal cross-reactivity, and compatibility with their experimental models to ensure reliable detection of DNAJC8 isoforms under varying conditions.
×
