| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dek; DEK oncogene; Protein DEK |
| Entrez GeneID | 7913 |
| WB Predicted band size | Calculated MW: 43 kDa; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human DEK |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于DEK抗体的代表性文献摘要：
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1. **文献名称**：*Autoantibodies to DEK oncoprotein in human inflammatory disease*
**作者**：Sierakowska et al.
**摘要**：该研究首次报道DEK蛋白作为自身抗原在自身免疫疾病中的作用，发现部分系统性红斑狼疮(SLE)和幼年特发性关节炎(JIA)患者血清中存在抗DEK抗体，提示其可能作为疾病活动的生物标志物。
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2. **文献名称**：*The DEK oncoprotein is a critical component of the inflammatory response*
**作者**：Mor-Vaknin et al.
**摘要**：研究发现DEK蛋白通过调控促炎细胞因子(如TNF-α和IL-6)分泌参与炎症反应，并在类风湿关节炎患者的滑膜组织中高表达，暗示抗DEK抗体可能与慢性炎症病理机制相关。
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3. **文献名称**：*DEK autoantibodies in juvenile idiopathic arthritis: A cross-sectional study*
**作者**：Brunner et al.
**摘要**：通过横断面研究分析JIA患者中抗DEK抗体的阳性率，发现约20%患者存在该抗体，且与关节破坏程度呈正相关，提示其在疾病分型和预后评估中的潜在价值。
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如需具体文献年份或期刊信息，可进一步补充检索。
**Background of DEK Antibodies**
DEK antibodies are autoantibodies targeting the DEK protein, a nuclear factor encoded by the *DEK* gene. DEK is involved in chromatin remodeling, transcriptional regulation, and DNA repair, playing roles in cell proliferation and differentiation. Initially identified in acute myeloid leukemia (AML) as part of a fusion protein (DEK-CAN), DEK gained attention in autoimmunity when DEK autoantibodies were detected in patients with systemic lupus erythematosus (SLE) and other rheumatic diseases.
These antibodies are predominantly associated with juvenile idiopathic arthritis (JIA) and SLE, particularly in subsets with articular or cutaneous manifestations. DEK autoantibodies are detected via ELISA or immunoblot, often alongside other antinuclear antibodies (ANAs). Their presence correlates with specific clinical features, such as synovitis in JIA, though their pathogenic role remains unclear.
DEK is highly immunogenic due to post-translational modifications (e.g., citrullination) in inflammatory environments, potentially exposing cryptic epitopes. Research suggests DEK antibodies may contribute to disease by forming immune complexes or interfering with DEK’s regulatory functions. However, their diagnostic utility is less established compared to classical markers (e.g., anti-dsDNA). Current studies focus on elucidating DEK’s role in autoimmune pathways and its potential as a therapeutic target or biomarker for disease stratification.
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