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Rabbit Monoclonal DDAH1 Antibody

  • 中文名： DDAH1抗体
  • 别    名： DDAH; DDAHI; DDAH-1; HEL-S-16
货号: IPDX21304
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDDAH; DDAHI; DDAH-1; HEL-S-16
Entrez GeneID23576
WB Predicted band sizeCalculated MW: 31 kDa; Observed MW: 31 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human DDAH1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于DDAH1抗体的模拟参考文献示例(基于常见研究主题构造，建议通过数据库核实具体文献)：

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1. **"Characterization of DDAH1-Specific Antibody for Detection of Endogenous Protein Expression"**

*Leiper, J. et al.*

摘要：本研究验证了一种高特异性DDAH1多克隆抗体的应用，通过Western blot和免疫荧光技术证实其在人内皮细胞及小鼠肾脏组织中的表达定位，并发现DDAH1表达水平与ADMA代谢活性呈正相关。

2. **"DDAH1 Deficiency Exacerbates Vascular Oxidative Stress in Hypertensive Rats"**

*Tain, Y.L. et al.*

摘要：文章利用DDAH1抗体进行蛋白质印迹分析，发现高血压大鼠模型中DDAH1表达下调导致ADMA积累，进而抑制一氧化氮合成，提示DDAH1抗体在心血管病理机制研究中的工具价值。

3. **"Tissue-Specific Distribution of DDAH1/2 Isoforms Revealed by Immunohistochemistry"**

*Pope, A.J. et al.*

摘要：通过商业化DDAH1抗体对多种哺乳动物组织进行免疫组化染色，揭示了DDAH1在肝脏、肾脏的高表达模式，并与DDAH2的组织分布差异对比，为研究两种同工酶的生理功能提供依据。

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**注**：以上为基于领域知识的模拟文献，实际文献需通过PubMed/Google Scholar以关键词“DDAH1 antibody”、“DDAH1 immunohistochemistry”等检索获取。

背景信息

The DDAH1 (dimethylarginine dimethylaminohydrolase 1) antibody is a research tool used to study the enzyme DDAH1. which plays a critical role in regulating nitric oxide (NO) synthesis. DDAH1 catalyzes the hydrolysis of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), thereby controlling NO bioavailability. This enzyme is implicated in cardiovascular, renal, and neurological functions, with dysregulation linked to hypertension, atherosclerosis, and endothelial dysfunction. DDAH1 antibodies are designed to detect and quantify the expression, localization, and activity of DDAH1 in various tissues and cell types. They are widely utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate DDAH1's role in disease models or physiological processes. Researchers also employ these antibodies to explore therapeutic strategies targeting DDAH1-ADMA-NO pathways. Commercially available DDAH1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of human, mouse, or rat DDAH1. Validation for specificity, sensitivity, and cross-reactivity is essential, as off-target binding can compromise experimental outcomes. Studies using DDAH1 antibodies have advanced understanding of endothelial dysfunction, oxidative stress, and metabolic disorders, highlighting their importance in both basic and clinical research.

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