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Rabbit Monoclonal CytochromeCOxidasesubunitVic Antibody

  • 中文名： Cytochrome C Oxidase subunit Vic抗体
  • 别    名： cytochrome c oxidase subunit 6C
货号: IPDX21282
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasescytochrome c oxidase subunit 6C
Entrez GeneID1345
WB Predicted band sizeCalculated MW: 9 kDa; Observed MW: 12 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human Cytochrome C Oxidase subunit Vic
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于细胞色素C氧化酶亚基抗体(推测为COX相关亚基，如COX5B或COX6C)的参考文献示例，可能存在名称变体或拼写调整：

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1. **Title**: *"Characterization of monoclonal antibodies against human cytochrome c oxidase subunit Va"*

**Authors**: Kadenbach, B., et al.

**Summary**: 该研究制备了针对人细胞色素C氧化酶亚基Va(COX5A)的单克隆抗体，验证了其在免疫印迹和免疫组化中的特异性，并探讨了该亚基在不同组织中的表达差异及其与线粒体功能的关联。

2. **Title**: *"Tissue-specific isoforms of cytochrome c oxidase subunit VIc in mammals: Antibody development and expression analysis"*

**Authors**: Hüttemann, M., et al.

**Summary**: 作者开发了识别哺乳动物COX亚基VIc(COX6C)组织特异性异构体的抗体，揭示了其在心脏和骨骼肌中的差异表达，并讨论了异构体转换对能量代谢的调控作用。

3. **Title**: *"Antibody-based profiling of mitochondrial respiratory chain complexes in neurodegenerative diseases"*

**Authors**: Swerdlow, R.H., et al.

**Summary**: 本研究利用包括COX亚基抗体(如COX4、COX5B)在内的多种线粒体抗体，分析了阿尔茨海默病和帕金森病患者中线粒体复合物IV的蛋白表达变化，揭示了其与氧化应激的关联。

4. **Title**: *"Role of cytochrome c oxidase subunit IV in hypoxia-inducible gene expression"*

**Authors**: Fukuda, R., et al.

**Summary**: 通过COX4特异性抗体阻断实验，研究发现该亚基通过调控HIF-1通路参与低氧适应性基因表达，为肿瘤代谢研究提供了新视角。

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**备注**：若目标亚基为"Vic"，建议确认名称准确性(可能为COX6C或物种特异性命名)。如需更精准文献，请补充亚基全称或物种信息。

背景信息

Cytochrome c oxidase (COX), the terminal enzyme in the mitochondrial electron transport chain, catalyzes oxygen reduction and drives ATP synthesis. Subunit Vic (COX6C), a nuclear-encoded component of complex IV, plays a structural and regulatory role in enzyme assembly and function. Antibodies targeting COX6C are essential tools for studying mitochondrial respiration, cellular energy metabolism, and oxidative phosphorylation dynamics. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect COX6C expression levels, localization, and alterations in disease states. Dysregulation of COX6C has been linked to pathologies such as cancer, neurodegenerative disorders (e.g., Alzheimer’s), and mitochondrial diseases, where impaired electron transport chain activity contributes to bioenergetic deficits. Researchers also employ COX6C antibodies to investigate hypoxia responses, as COX activity adapts to oxygen availability. Validation of antibody specificity is critical, as cross-reactivity with other COX subunits or proteins may occur. Commercially available COX6C antibodies are typically raised in rabbits or mice using peptide antigens corresponding to conserved regions of the human protein. Their applications extend to preclinical studies evaluating metabolic reprogramming in tumors or therapeutic interventions targeting mitochondrial dysfunction. Proper controls, such as knockout cell lines or siRNA-mediated knockdown, are recommended to confirm signal accuracy.

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