| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATL1 alpha; ATL1 beta; ATL1 gamma; ATL1 delta; Bcl11b; BCL11B/TRDC fusion; CTIP2; hRIT1 alpha; hRit1; Rit1 |
| Entrez GeneID | 64919 |
| WB Predicted band size | Calculated MW: 96 kDa; Observed MW: 120-130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Ctip2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Ctip2抗体的3篇参考文献示例(信息基于典型研究方向，具体文献需根据实际数据库查询)：
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1. **文献名称**: *Ctip2 controls dendritic differentiation of cortical pyramidal neurons*
**作者**: Arlotta, P. et al.
**摘要**: 本研究利用Ctip2抗体进行免疫组化分析，发现Ctip2在小鼠大脑皮层锥体神经元的分支形成中起关键作用，揭示了其在神经元形态发生中的调控机制。
2. **文献名称**: *Bcl11b/Ctip2 is required for T cell development*
**作者**: Wakabayashi, Y. et al.
**摘要**: 通过Ctip2抗体标记胸腺细胞，研究证明Ctip2对T淋巴细胞的分化至关重要，缺失会导致胸腺发育异常，强调了其在免疫系统中的作用。
3. **文献名称**: *Ctip2 marks a stem cell population in the hair follicle*
**作者**: Onder, T. et al.
**摘要**: 使用Ctip2抗体鉴定小鼠皮肤中的毛囊干细胞群，发现其通过调控Wnt信号通路维持干细胞自我更新能力，为皮肤再生研究提供依据。
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(注：以上为模拟示例，实际引用请通过PubMed/Google Scholar检索具体文献。)
The Ctip2 antibody targets the Ctip2 protein, also known as B-cell lymphoma/leukemia 11B (Bcl11b), a zinc-finger transcription factor encoded by the *BCL11B* gene. Ctip2 plays critical roles in cellular differentiation and development, particularly within the nervous and immune systems. It is essential for the maturation of cortical neurons, dendritic spine formation, and axonal projection in the brain, as well as T-cell lineage commitment and thymocyte development in the immune system.
Ctip2 antibodies are widely used in neuroscience and immunology research to study protein expression patterns and regulatory mechanisms in development and disease. These antibodies enable visualization and quantification of Ctip2 in tissues or cultured cells via techniques like immunohistochemistry, immunofluorescence, and Western blotting. Ctip2 is also implicated in pathological conditions, including neurodevelopmental disorders and cancers, making its antibody a valuable tool for exploring disease mechanisms.
As a nuclear protein, Ctip2’s localization and interaction with other transcription factors (e.g., COUP-TF) are key to its function. Researchers rely on specific, high-affinity Ctip2 antibodies to dissect its role in gene regulation networks. Validation of antibody specificity through knockout controls or siRNA is critical to ensure accurate experimental outcomes. Overall, the Ctip2 antibody serves as a cornerstone in studies of cellular identity, differentiation, and disease pathways.
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