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Rabbit Monoclonal CTA Antibody

  • 中文名： CT A抗体
  • 别    名： CCT A; CCT alph; CTPCT; PCYT1; Pcyt1a
货号: IPDX21255
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCCT A; CCT alph; CTPCT; PCYT1; Pcyt1a
Entrez GeneID5130
WB Predicted band sizeCalculated MW: 42 kDa; Observed MW: 42 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthetic peptide of human CT A
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于霍乱毒素A亚基(CT A)抗体的3篇参考文献示例(注：文献信息为模拟示例，实际引用请核实原文)：

1. **文献名称**：*"Neutralizing antibodies against cholera toxin A subunit inhibit toxin-induced cAMP signaling in intestinal epithelial cells"*

**作者**：Sanchez, J., & Holmgren, J.

**摘要**：研究证明，针对CT A亚基的单克隆抗体能够有效阻断霍乱毒素与宿主细胞表面受体结合，抑制毒素介导的cAMP信号通路激活，为基于抗体的治疗策略提供依据。

2. **文献名称**：*"Structural basis of cholera toxin neutralization by IgA antibodies from breast milk"*

**作者**：Lencer, W.I., et al.

**摘要**：通过X射线晶体学分析，揭示母乳中IgA抗体与CT A亚基的相互作用机制，发现抗体通过阻断毒素的酶活性结构域发挥中和作用，解释了母乳喂养对霍乱感染的防护机制。

3. **文献名称**：*"Cholera toxin A1-specific Fab fragments confer protection against toxin activity in vivo"*

**作者**：Matson, K.D., et al.

**摘要**：实验证明，针对CT A亚基酶活性区(A1片段)的Fab抗体片段可显著降低毒素在小鼠模型中的致病性，提示靶向A1区域的抗体具有治疗潜力。

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**备注**：上述文献为模拟内容，实际研究中可检索PubMed、Google Scholar等平台，关键词如“cholera toxin A subunit antibody”或“CT A neutralizing antibody”，并筛选高引用的经典论文或近年研究。

背景信息

CT antibodies target antigens produced by *Chlamydia trachomatis* (CT), a bacterial pathogen responsible for the most common sexually transmitted bacterial infections globally, including chlamydia, and ocular diseases like trachoma, a leading cause of preventable blindness. CT infections are often asymptomatic, complicating timely diagnosis and increasing risks of complications such as pelvic inflammatory disease, infertility, and ectopic pregnancy. Antibody detection plays a key role in serological diagnosis, particularly in chronic or disseminated cases where direct pathogen detection (e.g., PCR) may fail. CT-specific IgG, IgM, and IgA antibodies are measured using ELISA, immunofluorescence, or immunoblotting. IgG antibodies indicate past or ongoing infection, while IgM/IgA often suggest acute or active infection. However, serology has limitations: cross-reactivity with other *Chlamydia* species (e.g., *C. pneumoniae*) may occur, and antibody persistence post-treatment complicates distinguishing recent from prior infections. Research on CT antibodies also informs vaccine development, as neutralizing antibodies against major outer membrane proteins (MOMP) or polymorphic membrane proteins (Pmps) are potential targets. Despite advances, no licensed CT vaccine exists, underscoring the continued reliance on antibody-based diagnostics and epidemiological studies to monitor transmission and guide public health interventions.

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