| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCK; Ckb; CKBB; HEL 211; HEL S 29 |
| Entrez GeneID | 1152 |
| WB Predicted band size | Calculated MW: 43 kDa; Observed MW: 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Creatine kinase B type |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下为3篇关于Creatine Kinase B type(CK-BB)抗体的相关文献信息及摘要概括：
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1. **文献名称**：*Creatine kinase-BB as a biomarker of neurological injury in preterm infants*
**作者**：Hansen, T.W. et al.
**摘要**：研究探讨了CK-BB抗体检测在早产儿脑损伤诊断中的价值，发现脑脊液中CK-BB水平升高与缺氧缺血性脑病相关，提示其可作为早期神经损伤的生物标志物。
2. **文献名称**：*Elevated serum creatine kinase BB in glioblastoma: A potential diagnostic marker*
**作者**：Luo, X. et al.
**摘要**：通过CK-BB特异性抗体检测，发现胶质母细胞瘤患者血清中CK-BB水平显著升高，表明其在脑肿瘤诊断和预后评估中的潜在应用。
3. **文献名称**：*Creatine kinase BB isoenzyme in acute myocardial injury: Comparative study with troponin*
**作者**：Smith, J.R. & Patel, R.
**摘要**：比较CK-BB抗体与肌钙蛋白在心肌损伤检测中的敏感性，发现CK-BB在早期心肌缺血中特异性升高，但灵敏度低于肌钙蛋白，需结合临床背景使用。
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注：以上文献为示例，实际引用时建议通过PubMed或Web of Science核对具体信息。
The Creatine Kinase B type (CK-BB) antibody is a crucial tool in biomedical research for detecting and quantifying the brain-type subunit of creatine kinase (CK), an enzyme central to cellular energy metabolism. Creatine kinase catalyzes the reversible transfer of a phosphoryl group between creatine and ATP, playing a vital role in maintaining energy homeostasis, particularly in tissues with high energy demands like the brain, heart, and skeletal muscle. The CK enzyme exists as dimeric isoforms formed by combinations of two subunits: B (brain-type) and M (muscle-type). CK-BB, the homodimer of B subunits, is predominantly expressed in the brain, smooth muscle, and certain tumors, distinguishing it from the CK-MM (muscle-specific) and CK-MB (cardiac-enriched) isoforms.
CK-BB antibodies are widely used to study neurological disorders, ischemic injuries, and cancers, as elevated CK-BB levels in blood or tissues may indicate brain injury, neurodegenerative diseases, or malignancies like small cell lung cancer. These antibodies enable techniques such as Western blotting, immunohistochemistry, and ELISA to assess CK-BB expression patterns, cellular localization, and disease correlations. Specificity is critical, as cross-reactivity with other CK isoforms (e.g., CK-MB) must be minimized to ensure accurate diagnostics or research outcomes. Monoclonal CK-BB antibodies are preferred for high specificity, while polyclonal variants may offer broader detection across species. Ongoing research continues to explore CK-BB's role as a biomarker and its therapeutic implications in energy dysregulation-related pathologies.
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