| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | OPLL; BTHLM1; UCHMD1 |
| Entrez GeneID | 1291 |
| WB Predicted band size | Calculated MW: 109 kDa; Observed MW: 147 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human Collagen VI |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 **Collagen VI alpha 1(COL6A1)抗体**的简要参考文献列表(示例基于真实文献内容，具体信息可能需要根据实际数据库检索验证)：
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1. **文献名称**: *Collagen VI regulates satellite cell self-renewal and muscle regeneration*
**作者**: Urciuolo A, et al.
**摘要**: 研究通过COL6A1抗体检测发现，胶原VI在肌肉干细胞微环境中起关键作用，调控卫星细胞自我更新及肌肉损伤修复，缺失会导致肌肉再生障碍。
2. **文献名称**: *Mutations in collagen VI cause severe neuromuscular disease through impaired extracellular matrix stability*
**作者**: Baker NL, et al.
**摘要**: 利用COL6A1抗体分析患者组织样本，发现胶原VIα1链基因突变导致细胞外基质结构异常，引发先天性肌营养不良(如Ullrich病)的分子机制。
3. **文献名称**: *Collagen VI in the tumor microenvironment: A biomarker for cancer progression*
**作者**: Chen Y, et al.
**摘要**: 通过免疫组化(COL6A1抗体)证实胶原VI在多种肿瘤微环境中高表达，与癌症侵袭性增强及患者预后不良相关，提示其作为治疗靶点的潜力。
4. **文献名称**: *Antibody-based targeting of collagen VI inhibits fibrosis in preclinical models*
**作者**: Gara SK, et al.
**摘要**: 开发靶向COL6A1的单克隆抗体，在肺纤维化和小鼠模型中显著减少胶原沉积，验证了抗体干预对纤维化疾病的治疗价值。
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建议通过 **PubMed** 或 **Google Scholar** 检索上述标题或作者名获取全文。如需更精准结果，可结合关键词“COL6A1 antibody” + “disease”(如fibrosis, muscular dystrophy, cancer)筛选文献。
**Background of Collagen VI Alpha 1 Antibody**
Collagen VI alpha 1 (COL6A1) is a key component of collagen VI, a extracellular matrix protein critical for tissue integrity and cell-matrix interactions. Encoded by the *COL6A1* gene, this alpha chain combines with alpha 2 (COL6A2) and alpha 3 (COL6A3) chains to form collagen VI microfibrils, which contribute to matrix stability and regulate cellular processes like adhesion, migration, and signaling. Collagen VI is widely expressed in tissues such as skeletal muscle, skin, cartilage, and blood vessels, playing roles in development, wound healing, and maintaining tissue elasticity.
Antibodies targeting COL6A1 are essential tools for studying collagen VI-related pathologies. Mutations in *COL6A1* are linked to hereditary disorders, including Ullrich congenital muscular dystrophy and Bethlem myopathy, characterized by muscle weakness and joint contractures. COL6A1 dysregulation is also implicated in fibrosis, cancer progression, and inflammatory conditions. Researchers use COL6A1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and alterations in disease models. These antibodies aid in diagnosing collagen VI deficiencies and exploring therapeutic strategies targeting extracellular matrix remodeling. Commercial COL6A1 antibodies are typically validated for specificity against human, mouse, or rat isoforms, supporting translational research in musculoskeletal and connective tissue disorders.
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