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Rabbit Monoclonal COG6 Antibody

  • 中文名： COG6抗体
  • 别    名： COD2; SHNS; CDG2L
货号: IPDX21236
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCOD2; SHNS; CDG2L
Entrez GeneID57511
WB Predicted band sizeCalculated MW: 73 kDa; Observed MW: 73 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthetic peptide of human COG6
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于COG6抗体的模拟参考文献示例(内容为假设性概括，仅供格式参考)：

1. **"COG6 deficiency disrupts Golgi structure and glycosylation: Insights from a novel COG6-specific antibody"**

*Authors: Smith A, et al. (2022)*

**摘要**：本研究开发了一种高特异性COG6抗体，用于免疫荧光和Western blot分析。结果表明COG6缺失导致高尔基体碎片化，并影响蛋白质糖基化，为先天性糖基化障碍(CDG)的机制提供了新证据。

2. **"Anti-COG6 autoantibodies in autoimmune encephalitis: Clinical and diagnostic implications"**

*Authors: Chen L, et al. (2021)*

**摘要**：首次报道在自身免疫性脑炎患者血清中发现COG6自身抗体。通过ELISA和免疫组化验证抗体存在，提示其可能干扰高尔基体功能并与神经炎症相关。

3. **"Generation and validation of a monoclonal antibody targeting human COG6 for cancer biomarker studies"**

*Authors: Tanaka K, et al. (2020)*

**摘要**：研究团队制备了一种小鼠抗人COG6单克隆抗体，验证其在组织芯片中的适用性，发现COG6在结直肠癌中表达上调，可能与肿瘤转移相关。

4. **"CRISPR/Cas9-mediated COG6 knockout combined with antibody-based tracking reveals its role in lysosomal trafficking"**

*Authors: Müller R, et al. (2019)*

**摘要**：利用COG6抗体追踪基因敲除细胞模型，发现COG6缺失导致溶酶体酶运输缺陷，证实其在细胞内囊泡运输中的关键作用。

注：以上文献为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索(关键词：COG6 antibody, COG6 immunodetection)。

背景信息

The COG6 antibody is a research tool designed to detect the Conserved Oligomeric Golgi complex subunit 6 (COG6), a critical component of the COG complex. This multi-subunit protein complex (COG1–COG8) regulates vesicle trafficking and glycosylation within the Golgi apparatus, ensuring proper sorting and modification of proteins and lipids. COG6. along with COG5 and COG7. forms a subcomplex essential for maintaining Golgi structure and function. Mutations in the COG6 gene are linked to congenital disorders of glycosylation (CDG), notably COG6-CDG (also known as CDG-IIL), characterized by developmental delays, immune deficiencies, and neurological abnormalities. The COG6 antibody is widely used in studies investigating Golgi dynamics, protein trafficking defects, and molecular mechanisms underlying CDG. It enables the detection of COG6 expression levels, subcellular localization via immunofluorescence, and protein-protein interactions in techniques like Western blotting or immunoprecipitation. Researchers also employ this antibody to explore how COG6 dysfunction disrupts glycosylation pathways, contributing to disease pathology. Commercial COG6 antibodies are typically raised in rabbits or mice, targeting specific epitopes of human COG6. with validation in knockout controls to ensure specificity. Its applications span basic cell biology, clinical diagnostics, and therapeutic development for Golgi-related disorders.

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