| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Endopeptidase Clp |
| Entrez GeneID | 8192 |
| WB Predicted band size | Calculated MW: 30 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human CLPP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于CLPP抗体的3-4篇文献示例(注意：以下文献信息为模拟示例，实际引用需通过学术数据库核实)：
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1. **文献名称**: *"The CLPP subunit of the mitochondrial ATP-dependent protease regulates cancer cell apoptosis"*
**作者**: Hartmann-Petersen, R., et al.
**摘要**: 该研究探讨CLPP蛋白在线粒体ATP依赖性蛋白酶复合体中的作用，发现其通过调控错误折叠蛋白的降解参与细胞凋亡通路。研究利用特异性CLPP抗体验证其在多种癌细胞中的表达水平，并证明CLPP缺失会抑制线粒体应激诱导的凋亡。
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2. **文献名称**: *"Mitochondrial protease ClpP in stress response and protein quality control"*
**作者**: Haynes, C.M., et al.
**摘要**: 文章系统分析了ClpP在线粒体蛋白质量控制中的功能，指出其与氧化应激反应的关联。通过CLPP抗体进行免疫共沉淀实验，揭示了ClpP与其他线粒体蛋白(如ClpX)的相互作用机制，并发现其活性异常可能导致神经退行性疾病。
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3. **文献名称**: *"CLPP deficiency causes Perrault syndrome with hearing loss and ovarian failure"*
**作者**: Gispert, S., et al.
**摘要**: 该研究首次将CLPP基因突变与Perrault综合征(一种遗传性耳聋及卵巢早衰疾病)联系起来。通过患者细胞系中的CLPP抗体检测，发现突变导致CLPP蛋白水平显著下降，进而影响线粒体代谢和激素合成通路。
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4. **文献名称**: *"ClpP-dependent proteolysis regulates mitochondrial dynamics and neurodegeneration"*
**作者**: Jin, S.M., et al.
**摘要**: 研究聚焦CLPP在神经退行性疾病(如帕金森病)中的作用，利用CLPP抗体进行组织特异性敲除实验，证明ClpP通过降解错误折叠蛋白维持线粒体形态和功能，其功能缺失会加速神经元死亡。
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**说明**：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索最新文献，并核对作者、期刊及摘要准确性。关注关键词如“ClpP antibody”、“mitochondrial protease”、“protein degradation”等可提高检索效率。
CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit) is a mitochondrial protease belonging to the ATP-dependent Caseinolytic Protease (Clp) family, which is evolutionarily conserved across bacteria, plants, and mammals. In humans, CLPP functions as a critical component of the mitochondrial protein quality control system, forming a heteromeric complex with CLPX (regulatory ATPase subunit) to degrade misfolded or damaged proteins. It plays a vital role in maintaining mitochondrial homeostasis, stress responses, and regulating apoptosis. CLPP is also implicated in mitochondrial DNA replication and ribosome assembly.
Research has linked CLPP dysfunction to human diseases, particularly Perrault syndrome (a rare genetic disorder characterized by hearing loss and ovarian dysfunction) and other mitochondrial disorders. CLPP antibodies are essential tools for studying its expression, localization, and molecular mechanisms. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate CLPP's role in cellular stress responses, metabolic regulation, and disease pathogenesis. Given CLPP's conservation, antibodies often exhibit cross-reactivity with homologs in model organisms (e.g., mice), facilitating translational research. Recent studies also explore CLPP's potential as a therapeutic target in cancer and neurodegenerative diseases, driving demand for high-specificity antibodies to support mechanistic and diagnostic applications.
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