| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CIRP |
| Entrez GeneID | 1153 |
| WB Predicted band size | Calculated MW: 19 kDa; Observed MW: 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human CIRBP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇涉及CIRBP抗体的文献摘要概览：
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1. **文献名称**：*Cold-inducible RNA-binding protein (CIRBP) regulates intracellular antioxidant responses in macrophages*
**作者**：Liu AY, et al.
**摘要**：研究通过Western blot和免疫荧光技术，利用CIRBP抗体证实其在巨噬细胞氧化应激反应中的调控作用，发现CIRBP缺失导致抗氧化基因表达下降。
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2. **文献名称**：*CIRBP modulates tumor progression via NF-κB signaling in colorectal cancer*
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化(使用CIRBP特异性抗体)分析结直肠癌组织，发现CIRBP高表达与NF-κB通路激活及患者预后不良相关，提示其可作为潜在治疗靶点。
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3. **文献名称**：*Role of CIRBP in hypothermia-induced neuroprotection after traumatic brain injury*
**作者**：Sakurai T, et al.
**摘要**：研究利用CIRBP抗体检测低温处理下脑损伤模型中的蛋白表达变化，表明CIRBP通过抑制凋亡通路减轻神经元损伤，为神经保护机制提供依据。
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4. **文献名称**：*Antibody-based detection of CIRBP in sepsis-associated organ dysfunction*
**作者**：Chen X, et al.
**摘要**：通过ELISA和Western blot(使用抗CIRBP单克隆抗体)发现脓毒症患者血浆CIRBP水平升高，且与多器官衰竭严重程度正相关，提示其作为生物标志物的潜力。
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以上文献均聚焦于CIRBP在疾病中的作用机制，抗体主要用于蛋白定位、表达量检测及功能研究。如需具体文章链接或补充信息，可进一步提供方向。
CIRBP (Cold-Inducible RNA-Binding Protein) is a stress-responsive RNA-binding protein belonging to the glycine-rich RNA-binding protein family. It plays a regulatory role in post-transcriptional gene expression by influencing mRNA stability, splicing, and translation. Initially identified for its induction under mild hypothermia (32–35°C), CIRBP is also upregulated under other cellular stresses, including hypoxia, UV radiation, and nutrient deprivation. Its expression is linked to adaptive cellular processes such as cell cycle regulation, apoptosis, and inflammatory responses, making it relevant in cancer, neurodegenerative diseases, and ischemia-reperfusion injury studies.
CIRBP antibodies are essential tools for detecting and quantifying CIRBP protein levels in research. They enable the study of its subcellular localization, dynamic expression under stress conditions, and interactions with target mRNAs or proteins. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specificity validation often involves knockdown/knockout controls or recombinant protein blocking. Commercial CIRBP antibodies are typically developed against conserved epitopes, showing cross-reactivity in humans, mice, and rats.
Recent studies highlight CIRBP's dual role in diseases—it may promote tumor progression in certain cancers while exerting protective effects in neuronal or ischemic tissues. Research using CIRBP antibodies continues to unravel its context-dependent mechanisms, particularly its therapeutic potential in hypothermic medical interventions or stress-related pathologies.
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