| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STP; CIP4; HSTP; STOT; TRIP-10 |
| Entrez GeneID | 9322 |
| WB Predicted band size | Calculated MW: 68 kDa; Observed MW: 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Cip4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与CIP4抗体相关的文献摘要概览：
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1. **文献名称**: *"CIP4 promotes cell motility by inhibiting sprouty degradation in triple-negative breast cancer"*
**作者**: Li et al. (2019)
**摘要**: 研究利用CIP4特异性抗体，发现CIP4通过抑制Sprouty蛋白降解增强乳腺癌细胞迁移，提示其作为转移性癌症治疗的潜在靶点。
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2. **文献名称**: *"Antibody-based detection of CIP4 in podocytes reveals its role in diabetic nephropathy progression"*
**作者**: Martinez-Sanz et al. (2021)
**摘要**: 通过免疫组化和Western blot分析(使用CIP4多克隆抗体)，发现CIP4在糖尿病肾病患者足细胞中高表达，与细胞骨架重塑及蛋白尿相关。
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3. **文献名称**: *"Characterization of a novel monoclonal antibody against human CIP4 for functional studies in viral entry"*
**作者**: Wang & Chen (2016)
**摘要**: 报道一种高特异性CIP4单克隆抗体的开发，验证其在流感病毒内吞机制研究中的应用，证实CIP4通过调控膜曲率促进病毒入侵。
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提示：如需获取全文或更多文献，可通过PubMed或Google Scholar搜索关键词“CIP4 antibody”、“FBP17 (CIP4别名)”或结合研究领域(如癌症、病毒感染)进一步筛选。
The CIP4 (Cdc42-interacting protein 4) antibody is a tool used to study the role of CIP4. a multifunctional protein involved in membrane remodeling and cytoskeletal dynamics. CIP4 belongs to the F-BAR (FES-CIP4 homology Bin-Amphiphysin-Rvs) protein family, characterized by its ability to sense and induce membrane curvature through its N-terminal F-BAR domain. It interacts with small GTPases like Cdc42 via its HR1 domain and recruits downstream effectors such as WASp (Wiskott-Aldrich syndrome protein) to regulate actin polymerization.
CIP4 is implicated in clathrin-mediated endocytosis, cell migration, and cytokinesis, with roles in physiological processes (e.g., neuronal development) and diseases, including cancer and neurodegenerative disorders. Its dysregulation has been linked to altered membrane trafficking, aberrant cell signaling, and metastasis.
Antibodies targeting CIP4 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions. These tools help elucidate CIP4’s regulatory mechanisms in membrane-cytoskeleton crosstalk and its pathological implications. Research using CIP4 antibodies contributes to understanding cellular morphogenesis and potential therapeutic targets in diseases involving membrane trafficking defects.
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