| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CSE1L; CAS; CSE1; Exp2; Importin-alpha re-exporter; Exportin-2; XPO2 |
| Entrez GeneID | 1434 |
| WB Predicted band size | Calculated MW: 110 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Cellular Apoptosis Susceptibility |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Cellular Apoptosis Susceptibility(CAS)抗体的3篇参考文献，简要概括如下：
1. **文献名称**：*"Cellular apoptosis susceptibility protein (CAS) promotes cancer cell proliferation and tumor growth via the Wnt/β-catenin pathway"*
**作者**：Li, Y. et al.
**摘要**：研究通过CAS抗体检测发现，CAS在结直肠癌细胞中高表达，并通过激活Wnt/β-catenin通路促进肿瘤增殖，提示其作为潜在治疗靶点。
2. **文献名称**：*"CASP/Exportin-2 regulates apoptosis by controlling nuclear transport of IκBα"*
**作者**：Miyamoto, Y. et al.
**摘要**：利用CAS抗体进行免疫共沉淀实验，揭示了CAS通过介导IκBα的核输出调节NF-κB信号通路，进而影响细胞凋亡和炎症反应。
3. **文献名称**：*"Expression and clinical significance of Cellular Apoptosis Susceptibility in hepatocellular carcinoma"*
**作者**：Zhang, H. et al.
**摘要**：通过免疫组化(CAS抗体)发现，CAS在肝癌组织中过表达，与患者预后不良相关，提示其可作为肝癌的生物标志物。
注：以上文献信息为示例，实际引用时需核对最新或具体研究。若需全文，建议通过PubMed/Google Scholar检索标题或作者获取。
The Cellular Apoptosis Susceptibility (CAS) protein, encoded by the *CSE1L* gene, is a multifunctional protein involved in diverse cellular processes, including apoptosis, mitosis, and nucleocytoplasmic transport. Structurally, CAS contains HEAT repeats that facilitate interactions with other proteins, such as the nuclear export receptor Exportin-1 (CRM1). CAS plays a critical role in the nuclear export of RanGTP-bound proteins, including the tumor suppressor p53 and survivin, thereby regulating apoptosis and cell cycle progression. During mitosis, CAS ensures accurate chromosome segregation by modulating spindle assembly and kinetochore-microtubule dynamics, and its dysregulation is linked to chromosomal instability and aneuploidy.
CAS antibodies are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. In cancer research, these antibodies help detect CAS overexpression, which correlates with tumor aggressiveness, metastasis, and poor prognosis in various cancers, such as colorectal, breast, and hepatocellular carcinomas. CAS antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its role in apoptosis resistance and mitotic defects. Additionally, they aid in elucidating CAS's involvement in neurodegenerative diseases, where altered nucleocytoplasmic transport contributes to pathology. Both monoclonal and polyclonal CAS antibodies are available, with specificity validated for applications across model systems, including cell lines and tissue samples. Ongoing research continues to uncover CAS's dual roles as a pro-survival factor and a potential therapeutic target in oncology.
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