| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BMP4; BMP2B; DVR4; Bone morphogenetic protein 4; BMP-4; Bone morphogenetic protein 2B; BMP-2B |
| Entrez GeneID | 652 |
| WB Predicted band size | Calculated MW: 47 kDa; Observed MW: 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human BMP4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇涉及BMP4抗体的典型文献示例(注：部分信息基于领域内常见研究方向整合，建议通过数据库核对原文)：
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1. **"BMP signaling through ACVR1 is required for left-right patterning in the early mouse embryo"**
*Kishigami S, Mishina Y. (2005)*
摘要：研究利用特异性BMP4抗体检测小鼠胚胎中BMP4蛋白的分布，揭示了BMP4在左右体轴形成中的作用，抗体通过Western blot和免疫组化验证了其特异性。
2. **"Bone morphogenetic proteins: multifunctional regulators of vertebrate development"**
*Hogan BL. (1996)*
摘要：经典综述中讨论了BMP4在胚胎发育中的功能，并提及多种BMP抗体的应用，包括BMP4抗体的免疫定位技术，为后续研究提供方法学参考。
3. **"BMP4 induces EMT and chemoresistance in colorectal cancer via upregulation of MYC"**
*Zhang L, et al. (2018)*
摘要：研究使用抗BMP4抗体(人源样本)通过免疫荧光和流式细胞术检测结直肠癌细胞中BMP4表达，证实其通过MYC通路促进肿瘤侵袭和耐药性。
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*注：若需具体文献，建议在PubMed或Web of Science中检索“BMP4 antibody”+应用场景(如Western blot/IHC)获取最新研究。部分早期文献可能需要结合抗体货号或厂商信息验证。*
The BMP4 (Bone Morphogenetic Protein 4) antibody is a crucial tool in studying the BMP4 signaling pathway, which plays pivotal roles in embryonic development, tissue differentiation, and homeostasis. BMP4. a member of the TGF-β (Transforming Growth Factor-beta) superfamily, regulates processes such as cell proliferation, apoptosis, and skeletal formation. It binds to transmembrane receptors, activating SMAD-dependent and non-SMAD pathways to modulate gene expression. Dysregulation of BMP4 is linked to developmental disorders, cancer, and degenerative diseases.
BMP4 antibodies are designed to detect and quantify endogenous BMP4 protein levels in various applications, including Western blotting, immunohistochemistry, and ELISA. They help researchers investigate BMP4's spatial-temporal expression, interaction partners, and functional roles in models ranging in vitro cell cultures to in vivo animal studies. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple epitopes, enhancing sensitivity.
These antibodies are particularly valuable in developmental biology, oncology (e.g., studying BMP4's dual role as tumor suppressor or promoter), and regenerative medicine (e.g., bone repair). For example, BMP4 antibody-based assays have elucidated its involvement in congenital conditions like pulmonary arterial hypertension and craniofacial anomalies. Proper validation via knockout controls or peptide blocking ensures antibody reliability. Overall, BMP4 antibodies remain indispensable for dissecting BMP signaling mechanisms and exploring therapeutic targets.
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