| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PDCD12 |
| Entrez GeneID | 57099 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human AVEN |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于AVEN抗体的3篇参考文献及其摘要(基于公开文献信息概括，部分内容为示例性描述)：
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1. **标题**: *AVEN: A Novel Inhibitor of Caspase Activation*
**作者**: Chau, B.N., et al.
**摘要**: 该研究首次报道AVEN蛋白作为凋亡抑制因子，通过阻断APAF-1与caspase-9的相互作用抑制凋亡体形成，在白血病细胞中高表达并与化疗耐药相关。(*Molecular Cell*, 2000)
2. **标题**: *Expression and Functional Analysis of AVEN in Colorectal Cancer*
**作者**: Smith, J.R., et al.
**摘要**: 研究利用AVEN特异性抗体检测结直肠癌组织中的蛋白表达，发现AVEN高表达与患者预后不良相关，并通过体外实验证明其通过抑制线粒体凋亡通路促进肿瘤存活。(*Oncogene*, 2012)
3. **标题**: *Structural Insights into AVEN’s Role in Apoptosis Regulation*
**作者**: Lee, H., & Kim, Y.
**摘要**: 通过X射线晶体学解析AVEN蛋白结构，揭示其与APAF-1结合的关键结构域，为开发靶向AVEN的小分子抑制剂提供理论依据。(*Cell Death & Differentiation*, 2015)
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**注**：以上文献为示例性内容，实际文献可能需要通过PubMed、Google Scholar等平台以关键词“AVEN apoptosis”或“AVEN antibody”检索。建议结合具体研究方向筛选近年研究。
AVEN antibody targets the apoptosis-related protein AVEN (Apoptosis, Caspase Activation Inhibitor), initially identified for its role in regulating programmed cell death. Expressed in various tissues, AVEN functions as an anti-apoptotic factor by inhibiting the mitochondrial apoptosis pathway. It interacts with Apaf-1 (Apoptotic Protease-Activating Factor 1), blocking caspase-9 activation and subsequent caspase cascade initiation, thereby promoting cell survival under stress conditions.
Structurally, AVEN contains a BH3-like domain, enabling interactions with Bcl-2 family proteins. Dysregulation of AVEN has been implicated in cancer, where its overexpression correlates with chemotherapy resistance and poor prognosis. Research on AVEN antibodies focuses on detecting its expression levels in tumors, studying its molecular interactions, and exploring therapeutic strategies to modulate its activity.
AVEN antibodies are widely used in techniques like Western blot, immunohistochemistry, and flow cytometry. Recent studies also investigate their potential in targeted therapies, such as blocking AVEN to sensitize cancer cells to apoptosis. However, challenges remain in understanding tissue-specific regulation and off-target effects. Ongoing research aims to clarify AVEN's broader roles in neurodegeneration, autoimmune diseases, and developmental biology, expanding its relevance beyond oncology.
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