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Rabbit Monoclonal AP3M1 Antibody

  • 中文名： AP3M1抗体
  • 别    名： AP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu-1; Mu-adaptin 3A; Mu3A-adaptin
货号: IPDX21058
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu-1; Mu-adaptin 3A; Mu3A-adaptin
Entrez GeneID26985
WB Predicted band sizeCalculated MW: 47 kDa; Observed MW: 47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human AP3M1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于AP3M1抗体的3篇参考文献(基于公开数据模拟整理)：

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1. **文献名称**：*AP-3μ1 regulates neuronal amyloid-β protein generation via modulating BACE1 trafficking*

**作者**：Xu W. et al.

**摘要**：研究AP3M1在神经元中调控BACE1转运的作用，利用AP3M1抗体通过免疫共沉淀和Western blot验证其与BACE1的相互作用，揭示AP3M1缺失导致阿尔茨海默病相关β淀粉样蛋白异常积累的机制。

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2. **文献名称**：*The role of AP3M1 in lysosomal biogenesis and Hermansky-Pudlak syndrome*

**作者**：Dell'Angelica E.C. et al.

**摘要**：通过AP3M1抗体进行免疫荧光定位，证实AP3M1是AP-3复合体的关键亚基，参与溶酶体相关细胞器的生成，其突变与Hermansky-Pudlak综合征(HPS)的亚型相关。

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3. **文献名称**：*AP3M1 deficiency impairs platelet dense granule biogenesis and causes bleeding diathesis*

**作者**：Huizing M. et al.

**摘要**：利用AP3M1抗体检测患者血小板中蛋白表达，发现AP3M1缺陷导致血小板致密颗粒形成异常，阐明其突变引发出血倾向的分子病理机制。

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(注：以上文献信息为示例性模拟，实际引用请以具体文献内容为准。)

背景信息

The AP3M1 antibody targets the Adaptor Related Protein Complex 3 Subunit Mu 1 (AP3M1), a key component of the AP-3 complex involved in intracellular vesicle trafficking and protein sorting. The AP-3 complex mediates cargo transport from endosomes to lysosomes and lysosome-related organelles, such as melanosomes and platelet dense granules. AP3M1. the μ subunit, plays a critical role in recognizing tyrosine-based sorting signals on cargo proteins. Mutations in the AP3M1 gene are linked to Hermansky-Pudlak syndrome type 10 (HPS10), a rare genetic disorder characterized by oculocutaneous albinism, bleeding disorders, and immune dysfunction due to defects in lysosome-related organelle biogenesis. AP3M1 antibodies are widely used in research to study protein trafficking mechanisms, lysosomal function, and cellular organelle dynamics. They enable detection of AP3M1 expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into its role in neurological processes, immune regulation, and cancer biology. Validated antibodies help identify AP3M1 dysregulation in pathological contexts, offering insights into therapeutic targeting. Specificity is confirmed using knockout controls or siRNA knockdown, ensuring reliable experimental outcomes. These tools are essential for advancing understanding of AP3M1's contributions to cellular homeostasis and disease.

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