| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERF1; TFAP2G; hAP-2g; AP2-GAMMA |
| Entrez GeneID | 7022 |
| WB Predicted band size | Calculated MW: 49 kDa; Observed MW: 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human AP2 gamma |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Transcription Factor AP-2 gamma(TFAP2C)抗体的3篇代表性文献，供参考：
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1. **文献名称**：*TFAP2C regulates stemness in human embryonic stem cells and breast cancer*
**作者**：Werling, R.W. 等
**摘要**：该研究利用TFAP2C抗体(Western blot和免疫荧光)揭示了AP-2γ在维持人胚胎干细胞多能性中的作用，并发现其在乳腺癌中高表达，与肿瘤干细胞特性相关。
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2. **文献名称**：*AP-2γ is a critical regulator of female reproductive tract development*
**作者**：Kuckenberg, P. 等
**摘要**：通过免疫组化和小鼠模型，研究证明AP-2γ抗体标记的蛋白在雌性生殖系统发育中不可或缺，敲除后导致输卵管和子宫结构异常。
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3. **文献名称**：*TFAP2C promotes proliferation and chemoresistance in ovarian cancer*
**作者**：Huang, S. 等
**摘要**：使用TFAP2C抗体(ChIP-seq和IHC)发现AP-2γ通过调控细胞周期基因加速卵巢癌增殖，并介导化疗耐药性，提示其作为治疗靶点的潜力。
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注：以上文献为示例，实际引用时建议通过PubMed或期刊数据库核实具体信息。如需DOI或年份等细节，可进一步补充。
Transcription Factor AP-2 gamma (TFAP2C or AP-2γ) is a member of the AP-2 family of sequence-specific DNA-binding proteins, which regulate gene expression during embryonic development and cellular differentiation. AP-2γ plays critical roles in embryogenesis, particularly in trophoblast development, neural crest cell differentiation, and epidermal morphogenesis. It is also implicated in regulating cell proliferation, apoptosis, and oncogenesis, with elevated expression observed in cancers such as breast carcinoma and germ cell tumors.
Antibodies targeting AP-2γ are widely used in research to study its expression patterns, molecular interactions, and functional roles in both normal and pathological contexts. These antibodies enable detection of AP-2γ protein via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validating antibody specificity is essential due to structural similarities among AP-2 family members (AP-2α, β, δ, ε). AP-2γ antibodies typically recognize epitopes within the C-terminal region, which is less conserved across isoforms, ensuring reduced cross-reactivity.
In cancer research, AP-2γ antibodies help investigate its role as an oncogenic driver, particularly in hormone receptor-positive breast cancers, where it modulates estrogen receptor signaling. Additionally, these tools are vital for exploring AP-2γ's involvement in stem cell biology and reproductive system development. Proper validation using knockout controls or siRNA-mediated knockdown is recommended to confirm antibody reliability in experimental models.
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