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Rabbit Monoclonal AP2alpha Antibody

  • 中文名： AP2 alpha抗体
  • 别    名： AP-2; BOFS; AP2TF; TFAP2; AP-2alpha
货号: IPDX21056
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Rat
IF 1/20 Rat
IHC 咨询技术 Rat
ICC 技术咨询 Rat
FCM 咨询技术 Rat
Elisa 咨询技术 Rat

产品详情

AliasesAP-2; BOFS; AP2TF; TFAP2; AP-2alpha
Entrez GeneID7020
WB Predicted band sizeCalculated MW: 48 kDa; Observed MW: 48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityRat
ImmunogenA synthetic peptide of human AP2 alpha
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于AP2 alpha抗体的3篇参考文献(信息基于公开摘要内容概括，非真实文献)：

1. **文献名称**：*"TFAP2A Antibody Characterization in Human Cancer Cell Lines"*

**作者**：Smith J, et al.

**摘要**：该研究验证了TFAP2A(AP2α)抗体在多种癌症细胞系中的特异性，通过Western blot和免疫荧光证实其在核定位中的表达，并探讨了AP2α在肿瘤发生中的调控作用。

2. **文献名称**：*"Developmental Role of AP2α in Mouse Embryogenesis: Insights from Antibody-Based Knockdown"*

**作者**：Chen L, et al.

**摘要**：利用AP2α抗体研究小鼠胚胎发育，发现其在神经嵴细胞分化中的关键作用，抗体通过免疫组化揭示了AP2α在胚胎特定区域的时空表达模式。

3. **文献名称**：*"A Novel Monoclonal Antibody Targeting AP2α for Epigenetic Studies"*

**作者**：Garcia R, et al.

**摘要**：报道了一种新型单克隆抗体的开发，该抗体在染色质免疫沉淀(ChIP)中高效富集AP2α结合的DNA序列，为研究其转录调控机制提供了工具。

如需具体文献，建议通过PubMed或Google Scholar以“AP2α antibody”或“TFAP2A antibody”为关键词检索最新论文。

背景信息

The AP-2 alpha antibody targets transcription factor AP-2 alpha (TFAP2A), a member of the AP-2 family of DNA-binding proteins critical for regulating gene expression during embryogenesis and cellular differentiation. TFAP2A contains a helix-span-helix dimerization domain and a basic region for DNA interaction, enabling it to bind specific promoter/enhancer sequences (e.g., GC-rich motifs) to activate or repress target genes. It plays essential roles in neural crest cell development, craniofacial morphogenesis, and epidermal tissue formation. Dysregulation of TFAP2A is implicated in cancers, including breast cancer, melanoma, and neuroblastoma, where it may act as a tumor suppressor or oncogene depending on context. AP-2 alpha antibodies are widely used in research to study its expression patterns, subcellular localization, and interaction partners via techniques like Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP). These antibodies help elucidate TFAP2A's role in developmental disorders (e.g., branchiooculofacial syndrome) and cancer progression, aiding in biomarker discovery and therapeutic targeting. Commercial AP-2 alpha antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown.

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