| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SNX; ANX7; SYNEXIN |
| Entrez GeneID | 310 |
| WB Predicted band size | Calculated MW: 53 kDa; Observed MW: 51,47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Recombinant protein of human Annexin VII |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Annexin VII抗体的3篇参考文献示例(内容为虚构，仅作格式参考)：
1. **标题**: *"Characterization of Annexin VII in Membrane Repair: A Monoclonal Antibody Approach*
**作者**: Smith J, Brown K, Lee T.
**摘要**: 本文利用特异性Annexin VII单克隆抗体，通过免疫印迹和免疫荧光技术，验证了Annexin VII在细胞膜损伤修复中的作用，证明其与囊泡融合过程的关联。
2. **标题**: *"Annexin VII Expression in Neurodegenerative Diseases: An Immunohistochemical Study*
**作者**: Garcia R, Müller S, Chen L.
**摘要**: 研究使用兔源多克隆Annexin VII抗体，分析了阿尔茨海默病模型中Annexin VII的分布变化，发现其在大脑神经元突触中的异常聚集可能与疾病进展相关。
3. **标题**: *"Role of Annexin VII in Calcium-Dependent Exocytosis: Insights from Antibody Blocking Experiments*
**作者**: Wang Y, Suzuki H, Patel A.
**摘要**: 通过Annexin VII中和抗体阻断实验，揭示了该蛋白在钙离子触发分泌过程中的关键作用，并证实其与SNARE复合体的功能互作。
(注：以上文献为模拟示例，实际引用需查询真实数据库如PubMed。)
Annexin VII, also known as synexin, is a member of the annexin family of calcium-dependent phospholipid-binding proteins. It is encoded by the ANXA7 gene in humans and plays diverse roles in cellular processes such as membrane trafficking, exocytosis, endocytosis, and membrane repair. Structurally, Annexin VII consists of a unique N-terminal domain and a conserved C-terminal core containing four annexin repeats that mediate Ca²⁺-dependent interactions with phospholipid membranes. This protein is highly expressed in skeletal muscle, cardiac tissue, and the brain, where it participates in the regulation of intracellular calcium signaling and membrane dynamics.
Annexin VII antibodies are essential tools for studying its localization, expression, and functional mechanisms. Research has linked Annexin VII to pathological conditions, including cancer, neurodegenerative diseases, and muscular dystrophy, where its dysregulation may contribute to altered membrane repair or vesicle fusion. Antibodies targeting specific epitopes (e.g., N-terminal or C-terminal regions) enable applications such as Western blotting, immunofluorescence, and immunohistochemistry to investigate protein expression patterns or post-translational modifications. Some studies also utilize these antibodies to explore Annexin VII's role in cellular stress responses or its potential as a biomarker. Commercial Annexin VII antibodies are typically validated for specificity using knockout controls or siRNA-based silencing to ensure reliable experimental outcomes.
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