| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ALYREF; ALY; BEF; THOC4; THO complex subunit 4; Tho4; Ally of AML-1 and LEF-1; Aly/REF export factor; Transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF |
| Entrez GeneID | 10189 |
| WB Predicted band size | Calculated MW: 27 kDa; Observed MW: 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Aly |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Aly抗体的3篇参考文献示例，涵盖其功能、作用机制及相关疾病研究：
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1. **文献名称**：*The role of Aly/REF in mRNA export and its interaction with TAP*
**作者**：Katahira J, Strässer K, Podtelejnikov A et al.
**摘要**：本研究揭示了Aly/REF(THOC4)蛋白在mRNA出核转运中的关键作用，通过结合转录复合物TREX并招募TAP/NXF1受体，促进mRNA与核孔复合体的结合。实验表明Aly抗体可阻断mRNA输出，证实其调控基因表达的分子机制。
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2. **文献名称**：*Aly deficiency leads to defective B cell development and autoimmunity in mice*
**作者**：Sasaki Y, Ishii K, Ito S et al.
**摘要**：通过Aly缺陷小鼠模型，发现Aly蛋白对B细胞成熟至关重要。使用Aly抗体检测其表达，发现Aly缺失导致免疫球蛋白类别转换异常，引发自身免疫反应，提示Aly在免疫耐受中的潜在治疗价值。
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3. **文献名称**：*THOC4/Aly as a biomarker for acute myeloid leukemia progression*
**作者**：Wang L, Chen Z, Zhang Y et al.
**摘要**：研究利用Aly抗体检测THOC4在白血病细胞中的表达，发现其高表达与AML患者预后不良相关。机制研究表明，Aly通过调控致癌基因mRNA转运促进白血病细胞增殖，为靶向治疗提供新方向。
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注：以上文献为示例，实际引用需根据具体研究领域核实原文信息。若需更精准的文献，建议通过PubMed或专业数据库检索关键词"Aly antibody"或"THOC4 antibody"。
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