| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BBDS2, NPHS26 |
| Entrez GeneID | 3911 |
| WB Predicted band size | 400kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LAMA5. AA range:2381-2430 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于LAMA5抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
1. **"Laminin α5 is essential for basement membrane development and tissue integrity"**
- **作者**: Miner, J.H., et al.
- **摘要**: 该研究通过基因敲除小鼠模型，揭示LAMA5在胚胎发育中维持基底膜结构的关键作用。使用LAMA5抗体进行免疫组化分析，发现LAMA5缺失导致肾脏和肺的基底膜异常，引发器官功能障碍，表明其在组织形态发生中的必要性。
2. **"Targeting LAMA5 in tumor vasculature inhibits cancer progression"**
- **作者**: Nishiuchi, R., et al.
- **摘要**: 研究利用LAMA5抗体阻断肿瘤血管内皮细胞中的LAMA5功能，发现可显著抑制黑色素瘤和肺癌小鼠模型的血管生成及肿瘤转移。结果表明，LAMA5抗体通过干扰α5β1整合素信号通路，成为潜在抗癌治疗策略。
3. **"LAMA5 expression correlates with renal fibrosis and serves as a prognostic biomarker"**
- **作者**: Chen, J., et al.
- **摘要**: 通过免疫荧光和Western blot分析慢性肾病患者的肾组织，发现LAMA5抗体检测到的LAMA5表达水平与纤维化程度呈负相关。提示LAMA5可作为评估肾纤维化进展的生物标志物，并为干预治疗提供靶点。
4. **"Laminin α5 regulates epithelial cell adhesion and migration in wound healing"**
- **作者**: Suzuki, K., et al.
- **摘要**: 该研究利用LAMA5抗体抑制皮肤上皮细胞中的LAMA5功能，发现细胞粘附和迁移能力显著下降，导致伤口愈合延迟。证实LAMA5通过调控细胞-基质相互作用，在组织修复过程中发挥重要作用。
以上文献展示了LAMA5抗体在基础研究、疾病机制探索及治疗应用中的多样化用途。
The LAMA5 antibody targets laminin subunit alpha-5 (LAMA5), a critical component of laminin-511/521. a family of extracellular matrix (ECM) glycoproteins. Laminins play essential roles in cell adhesion, differentiation, and migration by interacting with cell surface receptors like integrins and dystroglycans. LAMA5. specifically, is a key subunit in basement membranes, particularly in epithelial and endothelial tissues, influencing tissue morphogenesis, angiogenesis, and embryonic development.
Research on LAMA5 antibodies has expanded due to their utility in studying ECM remodeling in diseases. LAMA5 dysregulation is implicated in cancer progression, fibrosis, and genetic disorders like Alport syndrome. Antibodies against LAMA5 enable detection of its expression and distribution in tissues, aiding investigations into its role in tumor invasion, metastasis, and vascular integrity. They are also used to explore regenerative processes, such as wound healing and stem cell niche maintenance.
Commercially available LAMA5 antibodies are typically developed in rabbit or mouse hosts, validated for techniques like Western blot, immunohistochemistry, and immunofluorescence. Challenges include ensuring specificity due to structural similarities among laminin isoforms. Recent studies highlight LAMA5 as a potential therapeutic target, driving demand for high-affinity, well-characterized antibodies. Overall, LAMA5 antibodies serve as vital tools for unraveling ECM biology and its implications in health and disease. (Word count: 247)
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